FLT3/CD135 Intracellular Domain

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FLT3/CD135 Intracellular Domain
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FLT3/CD135 Intracellular Domain

Original price was: $1,995.00.Current price is: $995.00.

Catalog Number: B2016897 (10 µg)
FLT3/CD135 Intracellular Domain is a high quality fragment of the human FLT3 receptor, also known as CD135, which is a cell surface receptor involved in the regulation of cell growth and differentiation. The intracellular domain of FLT3/CD135 is the portion of the receptor that is located inside the cell and is responsible for transmitting signals from the receptor to the cell’s interior. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Product Description

5/5 - (1 vote)

FLT3/CD135 Intracellular Domain
Catalog number: B2016897
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 µg
Molecular Weight or Concentration: 55 kDa
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -80°C
Keywords: Fetal Liver Kinase-2, FL Cytokine Receptor, FLK2, FMS-like Tyrosine Kinase 3, Receptor-type Tyrosine-protein Kinase, Stem Cell Tyrosine Kinase 1, STK1
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Heitmann JS, Schlenk RF, Dörfel D, Kayser S, Döhner K, Heuser M, Thol F, Kapp-Schwoerer S, Labrenz J, Edelmann D, Märklin M, Vogel W, Bethge W, Walz JS, Große-Hovest L, Steiner M, Jung G, Salih HR. Phase I study evaluating the Fc-optimized FLT3 antibody FLYSYN in AML patients with measurable residual disease J Hematol Oncol. 2023 Aug 17;16(1):96.
2: Koch S, Helbing I, Böhmer SA, Hayashi M, Claesson-Welsh L, Söderberg O, Böhmer FD. In Situ Proximity Ligation Assay (In Situ PLA) to Assess PTP-Protein Interactions Methods Mol Biol. 2016;1447:217-42.
3: Daver N, Schlenk RF, Russell NH, Levis MJ. Targeting FLT3 mutations in AML: review of current knowledge and evidence Leukemia. 2019 Feb;33(2):299-312.
4: Kennedy VE, Smith CC. FLT3 Mutations in Acute Myeloid Leukemia: Key Concepts and Emerging Controversies Front Oncol. 2020 Dec 23;10:612880.
5: Kiyoi H, Kawashima N, Ishikawa Y. FLT3 mutations in acute myeloid leukemia: Therapeutic paradigm beyond inhibitor development Cancer Sci. 2020 Feb;111(2):312-322.
6: Kazi JU, Rönnstrand L. FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications Physiol Rev. 2019 Jul 1;99(3):1433-1466.
7: Arai Y, Chi S, Minami Y, Yanada M. FLT3-targeted treatment for acute myeloid leukemia Int J Hematol. 2022 Sep;116(3):351-363.
8: Lv K, Ren JG, Han X, Gui J, Gong C, Tong W. Depalmitoylation rewires FLT3-ITD signaling and exacerbates leukemia progression Blood. 2021 Dec 2;138(22):2244-2255.
9: Grob T, Sanders MA, Vonk CM, Kavelaars FG, Rijken M, Hanekamp DW, Gradowska PL, Cloos J, Fløisand Y, van Marwijk Kooy M, Manz MG, Ossenkoppele GJ, Tick LW, Havelange V, Löwenberg B, Jongen-Lavrencic M, Valk PJM. Prognostic Value of FLT3-Internal Tandem Duplication Residual Disease in Acute Myeloid Leukemia J Clin Oncol. 2023 Feb 1;41(4):756-765.
10: Bystrom R, Levis MJ. An Update on FLT3 in Acute Myeloid Leukemia: Pathophysiology and Therapeutic Landscape Curr Oncol Rep. 2023 Apr;25(4):369-378.

Products Related to FLT3/CD135 Intracellular Domain can be found at Proteins

Additional Information

Weight 0.15 oz
Dimensions 2 × 0.5 × 0.5 in
5/5 - (1 vote)

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