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Fibroblast Growth Factor 23 (Human, Recombinant)

$395.00

Catalog Number: B2010302 (10 ug)
Fibroblast Growth Factor 23 (Human, Recombinant) is a high quality research product used as highly pure Fibroblast Growth Factor 23 (Human, Recombinant) expressed in E. coli. This protein acts as a unique FGF subfamily member that functions as as a hormone and requires α-Klotho to signal through the canonical FGFR, inducing hypertrophy and mineralization during chondrogenesis. Custom bulk orders of this product are available upon request.

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Description

Fibroblast Growth Factor 23 (Human, Recombinant)
Catalog number: B2010302
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Fibroblast Growth Factor 23 (Human, Recombinant) expressed in E. coli. This protein acts as a unique FGF subfamily member that functions as as a hormone and requires α-Klotho to signal through the canonical FGFR, inducing hypertrophy and mineralization during chondrogenesis.
Storage: -20C
Keywords: rHuFGF-23; Phosphatonin; Tumor-derived hypophosphatemia-inducing factor
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Ornitz DM, Itoh N. Fibroblast growth factors. Genome Biol.
2001;2(3):REVIEWS3005.

2: Degirolamo C, Sabbà C, Moschetta A. Therapeutic potential of the endocrine
fibroblast growth factors FGF19, FGF21 and FGF23. Nat Rev Drug Discov. 2016
Jan;15(1):51-69.

3: Pawlikowski B, Vogler TO, Gadek K, Olwin BB. Regulation of skeletal muscle
stem cells by fibroblast growth factors. Dev Dyn. 2017 May;246(5):359-367.

4: Turner N, Grose R. Fibroblast growth factor signalling: from development to
cancer. Nat Rev Cancer. 2010 Feb;10(2):116-29.

5: Li Q, Zhai Z, Li J. Fibroblast growth factor homologous factors are potential
ion channel modifiers associated with cardiac arrhythmias. Eur J Pharmacol. 2020
Mar 15;871:172920.

6: Thomas KA. Fibroblast growth factors. FASEB J. 1987 Dec;1(6):434-40.

7: Tucker B, Li H, Long X, Rye KA, Ong KL. Fibroblast growth factor 21 in non-
alcoholic fatty liver disease. Metabolism. 2019 Dec;101:153994.

8: Su X, Kong Y, Peng D. Fibroblast growth factor 21 in lipid metabolism and
non-alcoholic fatty liver disease. Clin Chim Acta. 2019 Nov;498:30-37.

9: Terwisscha van Scheltinga AF, Bakker SC, Kahn RS, Kas MJ. Fibroblast growth
factors in neurodevelopment and psychopathology. Neuroscientist. 2013
Oct;19(5):479-94.
10: Braun S, auf dem Keller U, Steiling H, Werner S. Fibroblast growth factors
in epithelial repair and cytoprotection. Philos Trans R Soc Lond B Biol Sci.
2004 May 29;359(1445):753-7.

Products Related to Fibroblast Growth Factor 23 (Human, Recombinant) : Proteins

Additional information

Weight 48 oz
Dimensions 8 × 8 × 8 in

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