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DNase1 Dockerine Chimeric Construct

$395.00

Catalog Number: B2012499 (10 ug)
DNase1 Dockerine Chimeric Construct is a high quality recombinant DNase-1 dockerine chimeric construct expressed in E. coli. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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SKU: B2012499 Categories: , Tag:

Description

DNase1 Dockerine Chimeric Construct
Catalog number: B2012499
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 ug
Molecular Weight or Concentration: 41.1 kDa
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: DNase I, DNL1
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Han DSC, Lo YMD. The Nexus of cfDNA and Nuclease Biology Trends Genet. 2021 Aug;37(8):758-770.
2: Han DSC, Ni M, Chan RWY, Chan VWH, Lui KO, Chiu RWK, Lo YMD. The Biology of Cell-free DNA Fragmentation and the Roles of DNASE1, DNASE1L3, and DFFB Am J Hum Genet. 2020 Feb 6;106(2):202-214.
3: Kenny EF, Raupach B, Abu Abed U, Brinkmann V, Zychlinsky A. Dnase1-deficient mice spontaneously develop a systemic lupus erythematosus-like disease Eur J Immunol. 2019 Apr;49(4):590-599.
4: Jiménez-Alcázar M, Rangaswamy C, Panda R, Bitterling J, Simsek YJ, Long AT, Bilyy R, Krenn V, Renné C, Renné T, Kluge S, Panzer U, Mizuta R, Mannherz HG, Kitamura D, Herrmann M, Napirei M, Fuchs TA. Host DNases prevent vascular occlusion by neutrophil extracellular traps Science. 2017 Dec 1;358(6367):1202-1206.
5: Lee YY, Park HH, Park W, Kim H, Jang JG, Hong KS, Lee JY, Seo HS, Na DH, Kim TH, Choy YB, Ahn JH, Lee W, Park CG. Long-acting nanoparticulate DNase-1 for effective suppression of SARS-CoV-2-mediated neutrophil activities and cytokine storm Biomaterials. 2021 Jan;267:120389.
6: Angeletti A, Volpi S, Bruschi M, Lugani F, Vaglio A, Prunotto M, Gattorno M, Schena F, Verrina E, Ravelli A, Ghiggeri GM. Neutrophil Extracellular Traps-DNase Balance and Autoimmunity Cells. 2021 Oct 5;10(10):2667.
7: Sharma S, Hofbauer TM, Ondracek AS, Chausheva S, Alimohammadi A, Artner T, Panzenboeck A, Rinderer J, Shafran I, Mangold A, Winker R, Wohlschläger-Krenn E, Moser B, Taghavi S, Klepetko W, Preissner KT, Lang IM. Neutrophil extracellular traps promote fibrous vascular occlusions in chronic thrombosis Blood. 2021 Feb 25;137(8):1104-1116.
8: Gatselis NK, Vakrakou AG, Zachou K, Androutsakos T, Azariadis K, Hatzis G, Manoussakis MN, Dalekos GN. Decreased serum DNase1-activity in patients with autoimmune liver diseases Autoimmunity. 2017 Mar;50(2):125-132.
9: Chrysanthopoulou A, Mitroulis I, Apostolidou E, Arelaki S, Mikroulis D, Konstantinidis T, Sivridis E, Koffa M, Giatromanolaki A, Boumpas DT, Ritis K, Kambas K. Neutrophil extracellular traps promote differentiation and function of fibroblasts J Pathol. 2014 Jul;233(3):294-307.
10: Dornase Alfa 2021 Jun 21. Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–.

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