[D-Arg1,D-Trp7,9,Leu11]-Substance P [Spantide]

Product Description

[D-Arg1,D-Trp7,9,Leu11]-Substance P [Spantide]
Catalog number: MDP0558
CAS Number: 171358-00-2
Sequence: D-Arg-Pro-Lys-Pro-Gln-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2
Amount: 500 ug
Molecular Weight: 1497.6 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Wiesenfeld-Hallin Z, Duranti R. D-Arg1, D-Trp7,9, Leu11-substance P (spantide) does not antagonize substance P-induced hyperexcitability of the nociceptive flexion withdrawal reflex in the rat Acta Physiol Scand. 1987 Jan;129(1):55-9.
2: Freedman J, Post C, Kåhrström J, Ohlen A, Mollenholt P, Owman C, Alari L, Hökfelt T. Vasoconstrictor effects in spinal cord of the substance P antagonist [D-Arg, D-Trp7,9 Leu11]-substance P (Spantide) and somatostatin and interaction with thyrotropin releasing hormone Neuroscience. 1988 Oct;27(1):267-78.
3: Fujino M, Kurosawa M, Saito H, Sato A, Swenson RS. Effects of a substance P analogue with antagonist properties ([D-Arg1, D-Trp7,9, Leu11]substance P) on spontaneous activity of the adrenal sympathetic nerve and its evoked reflex discharges in response to somatic afferent stimulation Neurosci Lett. 1987 Oct 5;80(3):315-20.
4: Bobyock E, Barbieri EJ, Chernick WS. Effects of substance P and substance P antagonists on rat salivary secretion J Dent Res. 1986 Dec;65(12):1427-31.
5: Eide PK. Effects of intrathecal substance P and a substance P antagonist on a reflex to noxious heat are independent of changes in tail skin temperature Acta Physiol Scand. 1990 Dec;140(4):539-43.
6: Jacoby HI, Lopez I, Wright D, Vaught JL. Differentiation of multiple neurokinin receptors in the guinea pig ileum Life Sci. 1986 Nov 24;39(21):1995-2003.
7: Wagner LE, Tomczuk BE, Yanni JM. Measurement of tachykinin-induced salivation in conscious rats J Pharmacol Methods. 1991 Aug;26(1):67-72.
8: Evans PD, Reale V, Merzon RM, Villegas J. Substance P modulation of the membrane potential of the Schwann cell of the squid giant nerve fibre Glia. 1990;3(5):393-404.
9: Tanabe T, Otani H, Bao L, Mikami Y, Yasukura T, Ninomiya T, Ogawa R, Inagaki C. Intracellular signaling pathway of substance P-induced superoxide production in human neutrophils Eur J Pharmacol. 1996 Mar 28;299(1-3):187-95.
10: Akasu T, Yamada K. Neurokinin-1 (NK1) receptors mediate tachykinin-induced depression of GABA current in bullfrog sensory neurons Kurume Med J. 1997;44(1):33-41.

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