[D-Ala2,D-Leu5]-Enkephalin

Product Description

[D-Ala2,D-Leu5]-Enkephalin
Catalog number: MDP0486
CAS Number: 114547-28-3
Sequence: Tyr-D-Ala-Gly-Phe-D-Leu . AcOH . H2O
Amount: 5 mg
Molecular Weight: 569.6 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Deschamps JR, George C, Flippen-Anderson JL. [D-Ala2,D-Leu5]-enkephalin hydrochloride Acta Crystallogr C. 1996 Jun 15;52 ( Pt 6):1583-5.
2: Lai Z, Gu L, Yu L, Chen H, Yu Z, Zhang C, Xu X, Zhang M, Zhang M, Ma M, Zhao Z, Zhang J. Delta opioid peptide [d-Ala2, d-Leu5] enkephalin confers neuroprotection by activating delta opioid receptor-AMPK-autophagy axis against global ischemia Cell Biosci. 2020 Jun 15;10:79.
3: Fu D, Liu H, Liu H, Yao J. Effects of D‑Ala2, D‑Leu5‑Enkephalin pre‑ and post‑conditioning in a rabbit model of spinal cord ischemia and reperfusion injury Mol Med Rep. 2019 Dec;20(6):4811-4820.
4: Hasegawa H, Nakamura A, Shinohara Y, Baba S. Determination of [D-Ala2,D-Leu5]enkephalin and the metabolites containing C-terminal D-leucine by high-performance liquid chromatography J Chromatogr B Biomed Sci Appl. 1997 Feb 21;689(2):287-94.
5: Zhang G, Lai Z, Gu L, Xu K, Wang Z, Duan Y, Chen H, Zhang M, Zhang J, Zhao Z, Wang S. Delta Opioid Receptor Activation with Delta Opioid Peptide [d-Ala2, d-Leu5] Enkephalin Contributes to Synaptic Improvement in Rat Hippocampus against Global Ischemia Cell Transplant. 2021 Jan-Dec;30:9636897211041585.
6: Havemann U, Winkler M, Kuschinsky K. The effects of D-ala2, D-Leu5-enkephalin injections into the nucleus accumbens on the motility of rats Life Sci. 1983;33 Suppl 1:627-30.
7: Tsushima H, Mori M, Matsuda T. Effects of D-Ala2-D-Leu5-enkephalin, microinjected into the supraoptic and paraventricular nuclei, on urine outflow rate Jpn J Pharmacol. 1993 Oct;63(2):181-6.
8: Wong-Dusting HK, Rand MJ. Effect of [D-Ala2,Met5]enkephalinamide and [D-Ala2,D-Leu5]enkephalin on cholinergic and noradrenergic neurotransmission in isolated atria Eur J Pharmacol. 1985 Apr 23;111(1):65-72.
9: Pang IH, Bernardini GL, Clark WG. Hyperthermic response of the cat to intraventricular injection of the opioid delta-receptor agonist D-Ala2-D-Leu5-enkephalin Brain Res Bull. 1984 Aug;13(2):263-8.
10: Rolka K, Kolasa K, Kleinrok Z, Kupryszewski G. Opiate-like peptides. Part VIII. Methylamides and dimethylamides of [D-Leu5]-enkephalin and [D-Ala2, D-Leu5]-enkephalin. Synthesis and analgesic activity Pol J Pharmacol Pharm. 1986 Jul-Aug;38(4):391-402.

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