Conantokin T

Product Description

Conantokin T
Catalog number: MDP0639
CAS Number: 141801-26-5
Sequence: Gly-Glu-Gla-Gla-Tyr-Gln-Lys-Met-Leu-Gla-Asn-Leu-Arg-Gla-Ala-Glu-Val-Lys-Lys-Asn-Ala-NH2 (Gla: L-γ-Carboxyglutamic acid)
Amount: 500 ug
Molecular Weight: 2683.6 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Liu Z, Yu Z, Yu S, Zhu C, Dong M, Mao W, Hu J, Prorok M, Su R, Dai Q. A Conantokin Peptide Con-T[M8Q] Inhibits Morphine Dependence with High Potency and Low Side Effects Mar Drugs. 2021 Jan 19;19(1):44.
2: Huang CC, Lyu PC, Lin CH, Hsu KS. Conantokin-T selectively antagonizes N-methyl-D-aspartate-evoked responses in rat hippocampal slice Toxicon. 1997 Mar;35(3):355-63.
3: Haack JA, Rivier J, Parks TN, Mena EE, Cruz LJ, Olivera BM. Conantokin-T. A gamma-carboxyglutamate containing peptide with N-methyl-d-aspartate antagonist activity J Biol Chem. 1990 Apr 15;265(11):6025-9.
4: Skjaerbaek N, Nielsen KJ, Lewis RJ, Alewood P, Craik DJ. Determination of the solution structures of conantokin-G and conantokin-T by CD and NMR spectroscopy J Biol Chem. 1997 Jan 24;272(4):2291-9.
5: Klein RC, Galdzicki Z, Castellino FJ. Inhibition of NMDA-induced currents by conantokin-G and conantokin-T in cultured embryonic murine hippocampal neurons Neuropharmacology. 1999 Dec;38(12):1819-29.
6: Klein RC, Castellino FJ. Inhibition of MK801 binding in adult rat brain sections by conantokin-G and conantokin-T Neurosci Lett. 1999 Oct 8;273(3):171-4.
7: Blandl T, Warder SE, Prorok M, Castellino FJ. Binding of cations to individual gamma-carboxyglutamate residues of conantokin-G and conantokin-T J Pept Res. 1999 Apr;53(4):453-64.
8: Prorok M, Warder SE, Blandl T, Castellino FJ. Calcium binding properties of synthetic gamma-carboxyglutamic acid-containing marine cone snail “sleeper” peptides, conantokin-G and conantokin-T Biochemistry. 1996 Dec 24;35(51):16528-34.
9: Warder SE, Blandl T, Klein RC, Castellino FJ, Prorok M. Amino acid determinants for NMDA receptor inhibition by conantokin-T J Neurochem. 2001 May;77(3):812-22.
10: Prorok M, Castellino FJ. Thermodynamics of binding of calcium, magnesium, and zinc to the N-methyl-D-aspartate receptor ion channel peptidic inhibitors, conantokin-G and conantokin-T J Biol Chem. 1998 Jul 31;273(31):19573-8.

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