(2-hydroxypropyl)-alpha-cyclodextrin Solution 10% (w/v)


Catalog Number: K1010005B (25 mL)
(2-hydroxypropyl)-alpha-cyclodextrin Solution 10% (w/v) is a highly pure solution of cyclic hydroxylated dextrin of type Alpha. This product has been used as versatile tools in molecular assemblies, enhancement of solubility and organic synthesis. It has also been used in a wide array of other biochemical and immunological applications. Custom bulk amounts of this product are available upon request.

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(2-hydroxypropyl)-alpha-cyclodextrin Solution 10% (w/v)
Catalog number: K1010005B
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 25 mL
Molecular Weight or Concentration: 10% (w/v)
Supplied as: Solution
Applications: versatile tools in molecular assemblies, enhancement of solubility and organic synthesis
Storage: 2-8C
Keywords: HPαCD, α‐HPCD, 2‐hydroxypropyl‐α‐CD, HP-α-CD, 2OHpαCD, (2-hydroxypropyl)-a-cyclodextrin
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Hoque S, Kondo Y, Sakata N, Yamada Y, Fukaura M, Higashi T, Motoyama K, Arima
H, Higaki K, Hayashi A, Komiya T, Ishitsuka Y, Irie T. Differential Effects of
2-Hydroxypropyl-Cyclodextrins on Lipid Accumulation in Npc1-Null Cells.
Int J Mol Sci. 2020 Jan 30;21(3):898.

2: Tomono K, Goto H, Suzuki T, Ueda H, Nagai T, Watanabe J. Interaction of
iodine with 2-hydroxypropyl-alpha-cyclodextrin and its bactericidal activity.
Drug Dev Ind Pharm. 2002 Nov;28(10):1303-9.

3: Motoyama K, Hashimoto Y, Hirayama F, Uekama K, Arima H. Inhibitory effects of
2,6-di-O-methyl-alpha-cyclodextrin on poly I:C signaling in macrophages. Eur J
Pharm Sci. 2009 Feb 15;36(2-3):285-91.

4: Holm R, Schönbeck C, Askjær S, Jensen H, Westh P, Østergaard J. Complexation
of tauro- and glyco-conjugated bile salts with α-cyclodextrin and hydroxypropyl-
α-cyclodextrin studied by affinity capillary electrophoresis and molecular
modelling. J Sep Sci. 2011 Nov;34(22):3221-30.

5: Zarzycki PK, Ohta H, Saito Y, Jinno K. Interaction of native alpha-
cyclodextrin, beta-cyclodextrin and gamma-cyclodextrin and their hydroxypropyl
derivatives with selected organic low molecular mass compounds at elevated and
subambient temperature under RP-HPLC conditions. Anal Bioanal Chem. 2008

6: Liu B, Li W, Nguyen TA, Zhao J. Empirical, thermodynamic and quantum-chemical
investigations of inclusion complexation between flavanones and
(2-hydroxypropyl)-cyclodextrins. Food Chem. 2012 Sep 15;134(2):926-32.

7: Terekhova IV, Scriba GK. Study on complex formation of biologically active
pyridine derivatives with cyclodextrins by capillary electrophoresis. J Pharm
Biomed Anal. 2007 Nov 30;45(4):688-93.

8: Rizzi V, Matera S, Semeraro P, Fini P, Cosma P. Interactions between
4-thiothymidine and water-soluble cyclodextrins: Evidence for supramolecular
structures in aqueous solutions. Beilstein J Org Chem. 2016 Mar 21;12:549-63.

9: Warne LN, Beths T, Whittem T, Carter JE, Bauquier SH. A review of the
pharmacology and clinical application of alfaxalone in cats. Vet J. 2015
10: Kimura K, Hirayama F, Arima H, Uekama K. Solid-state 13C nuclear magnetic
resonance spectroscopic study on amorphous solid complexes of tolbutamide with
2-hydroxypropyl-alpha- and -beta-cyclodextrins. Pharm Res. 1999

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