Collagen Type II, Monoclonal Antibody

Product Description

Collagen Type II, Monoclonal Antibody
Catalog number: B2026950
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 ug
Molecular Weight or Concentration: NA
Supplied as: Solution
Storage: −20°C
Keywords: Collagen Type II, Human Collagen, Native Collagen Type II, Undenatured Collagen Type II, Hydrolyzed Collagen Type II, Collagen Type II Alpha 1, COL2A1

References:
“1. Holmdahl R, Jansson L, Gullberg D, Rubin K, Forsberg PO, Klareskog L. Characterization of the antibody response in mice with type II collagen-induced arthritis, using monoclonal anti-type II collagen antibodies. Arthritis Rheum. 1986;29(3):400-410.
2. Nandakumar KS, Holmdahl R. Collagen type II-specific monoclonal antibody-induced arthritis in mice: description of the disease and the influence of age, sex, and genes. Am J Pathol. 2003;163(5):1827-1837.
3. Nandakumar KS, Svensson L, Holmdahl R. Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells. Arthritis Res Ther. 2004;6(6):R544-R550.
4. Uysal H, Sehnert B, Nandakumar KS, Boiers U, Burkhardt H, Holmdahl R, Thunnissen MM. The crystal structure of the pathogenic collagen type II-specific mouse monoclonal antibody CIIC1 Fab: structure to function analysis. Mol Immunol. 2008;45(8):2196-2204.
5. Boiers U, Nandakumar KS, Thunnissen MM, Holmdahl R. Collagen type II is recognized by a pathogenic antibody through germline encoded structures. Eur J Immunol. 2008;38(10):2784-2795.
6. Schulte S, Unger C, Mo ZA, Carlson MS, Kondratyeva AY, Glynn FE, Kern M, Curran ME. The LILRB receptor family and its role in immune regulation. Nat Rev Immunol. 2005;5(4):288-300.
7. Burkhardt H, Koller T, Engstrom A, Holmdahl R, Kalden JR. Epitope-specific recognition of type II collagen by synovial lymphocytes from patients with rheumatoid arthritis. Arthritis Rheum. 1995;38(2):191-200.
8. Nandakumar KS, Backlund J, Kern M, Holmdahl R. Collagen type II-specific antibodies and their role in the pathogenesis of arthritis. Curr Opin Rheumatol. 2008;20(3):311-316.
9. Khachigian LM. Collagen-induced arthritis. Methods Mol Biol. 2006;335:207-213.
10. Myers LK, Rosloniec EF, Cremer MA, Kang AH. Collagen-induced arthritis, an animal model of autoimmunity. Life Sci. 1997;61(19):1861-1878.”
Collagen Type II, Monoclonal Antibody (Clone CIIC1)

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