CGRP (Human)

Product Description

CGRP (Human)
Catalog number: MDP0539
CAS Number: 142191-63-7
Sequence: Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2 (Disulfide bond between Cys2-Cys7)
Amount: 500 ug
Molecular Weight: 3789.2 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Ashina H, Schytz HW, Ashina M. CGRP in human models of primary headaches Cephalalgia. 2018 Feb;38(2):353-360.
2: Bhakta M, Vuong T, Taura T, Wilson DS, Stratton JR, Mackenzie KD. Migraine therapeutics differentially modulate the CGRP pathway Cephalalgia. 2021 Apr;41(5):499-514.
3: Ashina H, Schytz HW, Ashina M. CGRP in Human Models of Migraine Handb Exp Pharmacol. 2019;255:109-120.
4: Deen M, Correnti E, Kamm K, Kelderman T, Papetti L, Rubio-Beltrán E, Vigneri S, Edvinsson L, Maassen Van Den Brink A; European Headache Federation School of Advanced Studies (EHF-SAS). Blocking CGRP in migraine patients – a review of pros and cons J Headache Pain. 2017 Sep 25;18(1):96.
5: Cohen E, Mariotton J, Rozenberg F, Sams A, van Kuppevelt TH, Barry Delongchamps N, Zerbib M, Bomsel M, Ganor Y. CGRP inhibits human Langerhans cells infection with HSV by differentially modulating specific HSV-1 and HSV-2 entry mechanisms Mucosal Immunol. 2022 Apr;15(4):762-771.
6: Shiers S, Klein RM, Price TJ. Quantitative differences in neuronal subpopulations between mouse and human dorsal root ganglia demonstrated with RNAscope in situ hybridization Pain. 2020 Oct;161(10):2410-2424.
7: Xu J, Wang J, Chen X, Li Y, Mi J, Qin L. The Effects of Calcitonin Gene-Related Peptide on Bone Homeostasis and Regeneration Curr Osteoporos Rep. 2020 Dec;18(6):621-632.
8: Evers S. CGRP in Childhood and Adolescence Migraine: (Patho)physiological and Clinical Aspects Curr Pain Headache Rep. 2022 Jun;26(6):475-480.
9: Labastida-Ramírez A, Rubio-Beltrán E, Villalón CM, MaassenVanDenBrink A. Gender aspects of CGRP in migraine Cephalalgia. 2019 Mar;39(3):435-444.
10: Holman JJ, Craig RK, Marshall I. Human alpha- and beta-CGRP and rat alpha-CGRP are coronary vasodilators in the rat Peptides. 1986 Mar-Apr;7(2):231-5.

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