CDK5 Substrate – (5-FAM) labeled

Product Description

CDK5 Substrate – (5-FAM) labeled
Catalog number: B2019494
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 1496.8
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: -20°C
Keywords: 5-FAM-PKTPKKAKKL
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Peyressatre M, Laure A, Pellerano M, Boukhaddaoui H, Soussi I, Morris MC. Fluorescent Biosensor of CDK5 Kinase Activity in Glioblastoma Cell Extracts and Living Cells Biotechnol J. 2020 Sep;15(9):e1900474.
2: Bosutti A, Qi J, Pennucci R, Bolton D, Matou S, Ali K, Tsai LH, Krupinski J, Petcu EB, Montaner J, Al Baradie R, Caccuri F, Caruso A, Alessandri G, Kumar S, Rodriguez C, Martinez-Gonzalez J, Slevin M. Targeting p35/Cdk5 signalling via CIP-peptide promotes angiogenesis in hypoxia PLoS One. 2013 Sep 30;8(9):e75538.
3: Schubert S, Knoch KP, Ouwendijk J, Mohammed S, Bodrov Y, Jäger M, Altkrüger A, Wegbrod C, Adams ME, Kim Y, Froehner SC, Jensen ON, Kalaidzidis Y, Solimena M. β2-Syntrophin is a Cdk5 substrate that restrains the motility of insulin secretory granules PLoS One. 2010 Sep 23;5(9):e12929.
4: Lee J, Yun N, Kim C, Song MY, Park KS, Oh YJ. Acetylation of cyclin-dependent kinase 5 is mediated by GCN5 Biochem Biophys Res Commun. 2014 Apr 25;447(1):121-7.
5: Corbel C, Zhang B, Le Parc A, Baratte B, Colas P, Couturier C, Kosik KS, Landrieu I, Le Tilly V, Bach S. Tamoxifen inhibits CDK5 kinase activity by interacting with p35/p25 and modulates the pattern of tau phosphorylation Chem Biol. 2015 Apr 23;22(4):472-482.
6: Hasan ASH, Dinh TTH, Le HT, Mizuno-Iijima S, Daitoku Y, Ishida M, Tanimoto Y, Kato K, Yoshiki A, Murata K, Mizuno S, Sugiyama F. Characterization of a bicistronic knock-in reporter mouse model for investigating the role of CABLES2 in vivo Exp Anim. 2021 Feb 6;70(1):22-30.
7: Huang Y, Huang W, Huang Y, Song P, Zhang M, Zhang HT, Pan S, Hu Y. Cdk5 Inhibitory Peptide Prevents Loss of Neurons and Alleviates Behavioral Changes in p25 Transgenic Mice J Alzheimers Dis. 2020;74(4):1231-1242.
8: Zhong P, Liu X, Zhang Z, Hu Y, Liu SJ, Lezama-Ruiz M, Joksimovic M, Liu QS. Cyclin-dependent kinase 5 in the ventral tegmental area regulates depression-related behaviors J Neurosci. 2014 Apr 30;34(18):6352-66.
9: Cho DH, Park JH, Joo Lee E, Jong Won K, Lee SH, Kim YH, Hwang S, Ja Kwon K, Young Shin C, Song KH, Jo I, Han SH. Valproic acid increases NO production via the SH-PTP1-CDK5-eNOS-Ser(116) signaling cascade in endothelial cells and mice Free Radic Biol Med. 2014 Nov;76:96-106.
10: Corbel C, Wang Q, Bousserouel H, Hamdi A, Zhang B, Lozach O, Ferandin Y, Tan VB, Guéritte F, Colas P, Couturier C, Bach S. First BRET-based screening assay performed in budding yeast leads to the discovery of CDK5/p25 interaction inhibitors Biotechnol J. 2011 Jul;6(7):860-70.

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