Cathepsin K Substrate II Fluorogenic

Description

Cathepsin K Substrate II Fluorogenic
Catalog number: B2014038
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 918.91 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: −20°C
Keywords: Cathepsin K Substrate II, Fluorogenic
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Lecaille F, Chazeirat T, Bojarski KK, Renault J, Saidi A, Prasad VGNV, Samsonov S, Lalmanach G. Rat cathepsin K: Enzymatic specificity and regulation of its collagenolytic activity Biochim Biophys Acta Proteins Proteom. 2020 Feb;1868(2):140318.
2: Mukherjee K, Chattopadhyay N. Pharmacological inhibition of cathepsin K: A promising novel approach for postmenopausal osteoporosis therapy Biochem Pharmacol. 2016 Oct 1;117:10-9.
3: Li Z, Hou WS, Escalante-Torres CR, Gelb BD, Bromme D. Collagenase activity of cathepsin K depends on complex formation with chondroitin sulfate J Biol Chem. 2002 Aug 9;277(32):28669-76.
4: Hwang HS, Chung HS. Preparation of active recombinant cathepsin K expressed in bacteria as inclusion body Protein Expr Purif. 2002 Aug;25(3):541-6.
5: Li Z, Hou WS, Brmme D. Collagenolytic activity of cathepsin K is specifically modulated by cartilage-resident chondroitin sulfates Biochemistry. 2000 Jan 25;39(3):529-36.
6: Lecaille F, Chowdhury S, Purisima E, Brmme D, Lalmanach G. The S2 subsites of cathepsins K and L and their contribution to collagen degradation Protein Sci. 2007 Apr;16(4):662-70.
7: Vasiljeva O, Reinheckel T, Peters C, Turk D, Turk V, Turk B. Emerging roles of cysteine cathepsins in disease and their potential as drug targets Curr Pharm Des. 2007;13(4):387-403.
8: de Melo Pereira D, Davison N, Habibovi P. Human osteoclast formation and resorptive function on biomineralized collagen Bioact Mater. 2021 Jul 15;8:241-252.
9: de Maat S, Clark CC, Boertien M, Parr N, Sanrattana W, Hofman ZLM, Maas C. Factor XII truncation accelerates activation in solution J Thromb Haemost. 2019 Jan;17(1):183-194.
10: Oliveira M, Torquato RJ, Alves MF, Juliano MA, Brmme D, Barros NM, Carmona AK. Improvement of cathepsin S detection using a designed FRET peptide based on putative natural substrates Peptides. 2010 Apr;31(4):562-7.

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