Big Gastrin (Human, highly pure)

Product Description

Price per 0.1 mg: $495
Catalog number: MDP0567
Name: Pyr-Leu-Gly-Pro-Gln-Gly-Pro-Pro-His-Leu-Val-Ala-Asp-Pro-Ser-Lys-Lys-Gln-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2
Other name(s): Big Gastrin (Human)
Molecular Formula: C₁₇₆H₂₅₁N₄₃O₅₃S
Molecular Mass: 3849.2
CAS #: 60675-77-6
Storage Temperature: -20 C

Indication for Use:
This product if for Research Use Only (RUO). This product is not for administration to humans or animals. This product is not for human or veterinary diagnostic or therapeutic use.

MSDS

About Big-Gastrin

Big gastrin (also known as G-34) is a peptide portion of gastrin containing 34 amino acids. It acts as a hormone produced by G cells of the stomach. G-34 has been shown to promote the secretion of gastric acid in certain species. Research has shown that extracts of antral mucosa contained large amounts of a peptide similar to the amino-terminal fragment of G34.

References

• Effect of antrectomy and drug-induced achlorhydria on urinary excretion of N-terminal biggastrin immunoreactivity in rats.
• Miyazaki Y, Shinomura Y, Yasunaga Y, Higashimoto Y, Kanayama S, Aoki T, Okuda Y, Narita T, Miwa K, Miyazaki I, et al. Regul Pept. 1993 Nov 19;49(1):49-56.
• Immunohistochemical examination of precursors, and g/CCK-2 receptor in human esophageal squamous cell carcinomas.
  Yuan A, Liu J, Liu Y, Bjørnsen T, Varro A, Cui G. Pathol Oncol Res. 2008 Dec;14(4):449-55.
• Sulfated stimulates ghrelin and growth hormone release but inhibits insulin secretion in cattle.
  Zhao H, Yannaing S, Thanthan S, Kuwayama H. Peptides. 2011 Nov;32(11):2218-24.
• Expression of gastrin, gastrin/CCK-B and gastrin/CCK-C receptors in human colorectal carcinomas.
  Imdahl A, Mantamadiotis T, Eggstein S, Farthmann EH, Baldwin GS. J Cancer Res Clin Oncol. 1995;121(11):661-6.
• Comparison of biological activity and disappearance rates of synthetic bg, little gastrin and minigastrin in the dog.
  Konturek SJ, Tasler J, Mikos E, Jaeger E, Wünsch E. Hepatogastroenterology. 1980 Feb;27(1):35-40.
• Interaction of synthetic human gastrin with blood proteins of man and animals.
  Polosatov MV, Klimov PK, Masevich CG, Samartsev MA, Wünsch E. Acta Hepatogastroenterol (Stuttg). 1979 Apr;26(2):154-9.