BAPTA AM (Highly Pure)


Catalog Number: B2012324 (5 mg)
BAPTA AM (Highly Pure) is a high quality BAPTA AM used as a membrane-impermeable calcium chelator that binds extracellular calcium ions . This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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BAPTA AM (Highly Pure)
Catalog number: B2012324
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 mg
Molecular Weight or Concentration: 764.7 g/mol
Supplied as: Crystals
Applications: molecular tool for various biochemical applications
Storage: -20C
Keywords: N,N’-[1,2-ethanediylbis(oxy-2,1-phenylene)]bis[N-[2-[(acetyloxy)methoxy]-2-oxoethyl]-1,1′-bis[(acetyloxy)methyl] ester-glycine
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Jing X, Wang Q, Du T, Zhang W, Liu X, Liu Q, Li T, Wang G, Chen F, Cui X. Calcium chelator BAPTA‑AM protects against iron overload‑induced chondrocyte mitochondrial dysfunction and cartilage degeneration Int J Mol Med. 2021 Oct;48(4):196.
2: Hu H, Mo X, Li X, Fu X, Hou Y. BAPTA-AM dramatically improves maturation and development of bovine oocytes from grade-3 cumulus-oocyte complexes Mol Reprod Dev. 2018 Jan;85(1):38-45.
3: Wu S, Canisso IF, Yang W, Ul Haq I, Liu Q, Han Y, Zeng S. Intracellular calcium chelating agent (BAPTA-AM) aids stallion semen cooling and freezing-thawing Reprod Domest Anim. 2018 Oct;53(5):1235-1242.
4: Li FJ, Tan KS, He CY. BAPTA-AM decreases cellular pH, inhibits acidocalcisome acidification and autophagy in amino acid-starved T. brucei Mol Biochem Parasitol. 2017 Apr;213:26-29.
5: Liu L, Wu N, Wang Y, Zhang X, Xia B, Tang J, Cai J, Zhao Z, Liao Q, Wang J. TRPM7 promotes the epithelial-mesenchymal transition in ovarian cancer through the calcium-related PI3K / AKT oncogenic signaling J Exp Clin Cancer Res. 2019 Feb 28;38(1):106.
6: Zheng F, Hang T, Wu C, Di B, Liu W, Xu J, Zhai C, Sun D, Liu J, Wei W. Determination of BAPTA-AM, the acetoxymethyl tetraester of BAPTA, in rat plasma by liquid chromatography tandem mass spectrometry J Mass Spectrom. 2006 Dec;41(12):1615-22.
7: Urbano FJ, Buño W. BAPTA-AM blocks both voltage-gated and Ca2+-activated K+ currents in cultured bovine chromaffin cells Neuroreport. 1998 Oct 26;9(15):3403-7.
8: Zhou S, Yuan X, Liu Q, Zhang X, Pan X, Zang L, Xu L. BAPTA-AM, an intracellular calcium chelator, inhibits RANKL-induced bone marrow macrophages differentiation through MEK/ERK, p38 MAPK and Akt, but not JNK pathways Cytokine. 2010 Dec;52(3):210-4.
9: Hsu SS, Lin YS, Liang WZ. Mechanism of action of a diterpene alkaloid hypaconitine on cytotoxicity and inhibitory effect of BAPTA-AM in HCN-2 neuronal cells Clin Exp Pharmacol Physiol. 2021 May;48(5):801-810.
10: Wie MB, Koh JY, Won MH, Lee JC, Shin TK, Moon CJ, Ha HJ, Park SM, Kim HC. BAPTA/AM, an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures Prog Neuropsychopharmacol Biol Psychiatry. 2001 Nov;25(8):1641-59.

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