Bacterial Type I Signal Peptidase FRET Substrate

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Bacterial type I signal Peptidase FRET Substrate
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Bacterial Type I Signal Peptidase FRET Substrate

Original price was: $1,395.00.Current price is: $695.00.

Catalog Number: B2011397 (1 mg)
Bacterial Type I Signal Peptidase FRET Substrate is a molecule designed to be cleaved by the bacterial enzyme Type I signal peptidase (SPase I). It is labeled with FRET (flourescence resonance energy transfer). This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

Live enquiry about this product via Text/SMS: 1-858-900-3210.

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SKU: B2011397 Categories: , Tag:

Product Description

4.8/5 - (6 votes)

Bacterial Type I Signal Peptidase FRET Substrate
Catalog number: B2011397
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 1494.6 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: SPase1 substrate
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: SzaÅ‚aj N, Benediktsdottir A, Rusin D, Karlén A, Mowbray SL, WiÄ™ckowska A. Bacterial type I signal peptidase inhibitors – Optimized hits from nature Eur J Med Chem. 2022 Aug 5;238:114490.
2: Craney A, Romesberg FE. The inhibition of type I bacterial signal peptidase: Biological consequences and therapeutic potential Bioorg Med Chem Lett. 2015 Nov 1;25(21):4761-4766.
3: Tuteja R. Type I signal peptidase: an overview Arch Biochem Biophys. 2005 Sep 15;441(2):107-11.
4: Smitha Rao CV, Anné J. Bacterial type I signal peptidases as antibiotic targets Future Microbiol. 2011 Nov;6(11):1279-96.
5: Benediktsdottir A, Lu L, Cao S, Zamaratski E, Karlén A, Mowbray SL, Hughes D, Sandström A. Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation Eur J Med Chem. 2021 Nov 15;224:113699.
6: Paetzel M. Structure and mechanism of Escherichia coli type I signal peptidase Biochim Biophys Acta. 2014 Aug;1843(8):1497-508.
7: Siegel SD, Wu C, Ton-That H. A Type I Signal Peptidase Is Required for Pilus Assembly in the Gram-Positive, Biofilm-Forming Bacterium Actinomyces oris J Bacteriol. 2016 Jul 13;198(15):2064-73.
8: Hazenbos WL, Skippington E, Tan MW. Staphylococcus aureus type I signal peptidase: essential or not essential, that’s the question Microb Cell. 2017 Mar 17;4(4):108-111.
9: Paetzel M. Bacterial Signal Peptidases Subcell Biochem. 2019;92:187-219.
10: Powers ME, Smith PA, Roberts TC, Fowler BJ, King CC, Trauger SA, Siuzdak G, Romesberg FE. Type I signal peptidase and protein secretion in Staphylococcus epidermidis J Bacteriol. 2011 Jan;193(2):340-8.

Products Related to Bacterial Type I Signal Peptidase FRET Substrate can be found at Substrates

Additional Information

Weight 0.15 oz
Dimensions 2 × 0.5 × 0.5 in
4.8/5 - (6 votes)

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