Bacterial type I signal Peptidase FRET Substrate

Description

Bacterial type I signal Peptidase FRET Substrate
Catalog number: B2011397
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 1494.6 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: SPase1 substrate
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Szałaj N, Benediktsdottir A, Rusin D, Karlén A, Mowbray SL, Więckowska A. Bacterial type I signal peptidase inhibitors – Optimized hits from nature Eur J Med Chem. 2022 Aug 5;238:114490.
2: Craney A, Romesberg FE. The inhibition of type I bacterial signal peptidase: Biological consequences and therapeutic potential Bioorg Med Chem Lett. 2015 Nov 1;25(21):4761-4766.
3: Tuteja R. Type I signal peptidase: an overview Arch Biochem Biophys. 2005 Sep 15;441(2):107-11.
4: Smitha Rao CV, Anné J. Bacterial type I signal peptidases as antibiotic targets Future Microbiol. 2011 Nov;6(11):1279-96.
5: Benediktsdottir A, Lu L, Cao S, Zamaratski E, Karlén A, Mowbray SL, Hughes D, Sandström A. Antibacterial sulfonimidamide-based oligopeptides as type I signal peptidase inhibitors: Synthesis and biological evaluation Eur J Med Chem. 2021 Nov 15;224:113699.
6: Paetzel M. Structure and mechanism of Escherichia coli type I signal peptidase Biochim Biophys Acta. 2014 Aug;1843(8):1497-508.
7: Siegel SD, Wu C, Ton-That H. A Type I Signal Peptidase Is Required for Pilus Assembly in the Gram-Positive, Biofilm-Forming Bacterium Actinomyces oris J Bacteriol. 2016 Jul 13;198(15):2064-73.
8: Hazenbos WL, Skippington E, Tan MW. Staphylococcus aureus type I signal peptidase: essential or not essential, that’s the question Microb Cell. 2017 Mar 17;4(4):108-111.
9: Paetzel M. Bacterial Signal Peptidases Subcell Biochem. 2019;92:187-219.
10: Powers ME, Smith PA, Roberts TC, Fowler BJ, King CC, Trauger SA, Siuzdak G, Romesberg FE. Type I signal peptidase and protein secretion in Staphylococcus epidermidis J Bacteriol. 2011 Jan;193(2):340-8.

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