APETx2

Product Description

APETx2
Catalog number: MDP0826
CAS Number: 1678415-52-5
Sequence: Gly-Thr-Ala-Cys-Ser-Cys-Gly-Asn-Ser-Lys-Gly-Ile-Tyr-Trp-Phe-Tyr-Arg-Pro-Ser-Cys-Pro-Thr-Asp-Arg-Gly-Tyr-Thr-Gly-Ser-Cys-Arg-Tyr-Phe-Leu-Gly-Thr-Cys-Cys-Thr-Pro-Ala-Asp (Reported disulfide bonds between Cys4-Cys37, Cys6-Cys30, Cys20-Cys38)
Amount: 100 ug
Molecular Weight: 4560.8 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Bian J, Cai F, Chen H, Tang Z, Xi K, Tang J, Wu L, Xu Y, Deng L, Gu Y, Cui W, Chen L. Modulation of Local Overactive Inflammation via Injectable Hydrogel Microspheres Nano Lett. 2021 Mar 24;21(6):2690-2698.
2: Yuan L, Xiao H, Li H, Yan B. APETx2 regulates intestinal motility and visceral sensitivity in post-infectious irritable bowel syndrome mice through 5-HT signalling pathway J Pharm Pharmacol. 2023 Apr 17;75(5):712-717.
3: Yen LT, Hsieh CL, Hsu HC, Lin YW. Preventing the induction of acid saline-induced fibromyalgia pain in mice by electroacupuncture or APETx2 injection Acupunct Med. 2020 Jun;38(3):188-193.
4: Diochot S, Baron A, Rash LD, Deval E, Escoubas P, Scarzello S, Salinas M, Lazdunski M. A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons EMBO J. 2004 Apr 7;23(7):1516-25.
5: Blanchard MG, Rash LD, Kellenberger S. Inhibition of voltage-gated Na(+) currents in sensory neurones by the sea anemone toxin APETx2 Br J Pharmacol. 2012 Apr;165(7):2167-77.
6: Lee JYP, Saez NJ, Cristofori-Armstrong B, Anangi R, King GF, Smith MT, Rash LD. Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain Br J Pharmacol. 2018 Jun;175(12):2204-2218.
7: Karczewski J, Spencer RH, Garsky VM, Liang A, Leitl MD, Cato MJ, Cook SP, Kane S, Urban MO. Reversal of acid-induced and inflammatory pain by the selective ASIC3 inhibitor, APETx2 Br J Pharmacol. 2010 Oct;161(4):950-60.
8: Anangi R, Rash LD, Mobli M, King GF. Functional expression in Escherichia coli of the disulfide-rich sea anemone peptide APETx2, a potent blocker of acid-sensing ion channel 3 Mar Drugs. 2012 Jul;10(7):1605-1618.
9: Anangi R, Chen CC, Lin YW, Cheng YR, Cheng CH, Chen YC, Chu YP, Chuang WJ. Expression in Pichia pastoris and characterization of APETx2, a specific inhibitor of acid sensing ion channel 3 Toxicon. 2010 Dec;56(8):1388-97.
10: Chagot B, Escoubas P, Diochot S, Bernard C, Lazdunski M, Darbon H. Solution structure of APETx2, a specific peptide inhibitor of ASIC3 proton-gated channels Protein Sci. 2005 Aug;14(8):2003-10.

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