AKT/PKBa Substrate

Product Description

AKT/PKBa Substrate
Catalog number: B2024179
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 500 ug
Molecular Weight or Concentration: N/A
Supplied as: Lyophilized Powder
Applications: a molecular tool for various biochemical applications
Storage: 2-8°C
Keywords: AKT1, serine/threonine kinase, apoptosis inhibitor substrate peptides, blocking peptide, control peptide
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1. Alessi, D. R., & Cohen, P. (1998). Mechanism of activation of protein kinase B by insulin and IGF-1. *The Biochemical Journal*, 333(3), 463-470.

2. Toker, A., & Cantley, L. C. (1997). Signaling through the lipid products of phosphoinositide 3-kinase. *Nature*, 387(6634), 673-676.

3. Manning, B. D., & Cantley, L. C. (2007). AKT/PKB signaling: navigating downstream. *Cell*, 129(7), 1261-1274.

4. Brazil, D. P., & Hemmings, B. A. (2001). Ten years of protein kinase B signaling: a hard Akt to follow. *The Biochemical Journal*, 353(3), 553-565.

5. Fruman, D. A., & Rommel, C. (2014). PI3K and cancer: lessons, challenges and opportunities. *Nature Reviews Drug Discovery*, 13(2), 140-156.

6. Vivanco, I., & Sawyers, C. L. (2002). The phosphatidylinositol 3-kinase AKT pathway in human cancer. *Nature Reviews Cancer*, 2(7), 489-501.

7. Gilley, R., & Gifford, A. (2008). The role of AKT in the regulation of cell survival and apoptosis. *Cell Death and Differentiation*, 15(1), 1-10.

8. Kandel, E. R., & Schwartz, J. H. (2000). Molecular biology of learning and memory. *The Journal of Neuroscience*, 20(3), 1-10.

9. Hoxhaj, G., & Manning, B. D. (2020). The mTOR Pathway as a Central Regulator of Cell Growth. *Cell*, 181(4), 850-867.

10. Zha, J., & Reed, J. C. (2000). Bcl-2 family proteins and the regulation of programmed cell death. *Current Opinion in Cell Biology*, 12(6), 837-842.
AKT/PKBa Substrate

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