Name: Aiolos Antibody Monoclonal
Brand: Molecular Depot
SKU: B2016932
Price: 695 USD
Availability: InStock
Rating: 5 (2 reviews)

Sale!

Aiolos Antibody Monoclonal

Original price was: $1,395.00.Current price is: $695.00.

Catalog Number: B2016932 (10 µl)
Aiolos Antibody Monoclonal is a high quality antibody that specifically targets the Aiolos protein. Aiolos is a transcription factor that plays a role in regulating gene expression in immune cells, particularly in B cells and T cells. Monoclonal antibodies targeting Aiolos may be used in research applications to study or modulate immune responses. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

Live enquiry about this product via Text/SMS: 1-858-900-3210.

In stock

SKU: B2016932 Categories: Antibodies, Cell Biology Tag: MD 1000

Product Description

5/5 - (2 votes)

Aiolos Antibody Monoclonal
Catalog number: B2016932
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 µl
Molecular Weight or Concentration: 70 kDa
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: -20°C
Keywords: IKZF3, AIO, ZNFN1A3
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Varma G, Goldstein J, Advani RH. Novel agents in relapsed/refractory diffuse large B-cell lymphoma Hematol Oncol. 2023 Jun;41 Suppl 1:92-106.
2: Read KA, Jones DM, Pokhrel S, Hales EDS, Varkey A, Tuazon JA, Eisele CD, Abdouni O, Saadey A, Leonard MR, Warren RT, Powell MD, Boss JM, Hemann EA, Yount JS, Xin G, Ghoneim HE, Lio CJ, Freud AG, Collins PL, Oestreich KJ. Aiolos represses CD4(+) T cell cytotoxic programming via reciprocal regulation of T(FH) transcription factors and IL-2 sensitivity Nat Commun. 2023 Mar 24;14(1):1652.
3: Hung KH, Su ST, Chen CY, Hsu PH, Huang SY, Wu WJ, Chen MJ, Chen HY, Wu PC, Lin FR, Tsai MD, Lin KI. Aiolos collaborates with Blimp-1 to regulate the survival of multiple myeloma cells Cell Death Differ. 2016 Jul;23(7):1175-84.
4: Wang JH, Avitahl N, Cariappa A, Friedrich C, Ikeda T, Renold A, Andrikopoulos K, Liang L, Pillai S, Morgan BA, Georgopoulos K. Aiolos regulates B cell activation and maturation to effector state Immunity. 1998 Oct;9(4):543-53.
5: Kikuchi H, Yamashita K, Nakayama M, Toyonaga K, Tsuneyoshi I, Takasaki M, Nakayama T. Lacking of Aiolos accelerates pre-mature B cell apoptosis mediated by BCR signaling through elevation in cytochrome c release Biochim Biophys Acta. 2009 Jul;1793(7):1304-14.
6: Cortés M, Georgopoulos K. Aiolos is required for the generation of high affinity bone marrow plasma cells responsible for long-term immunity J Exp Med. 2004 Jan 19;199(2):209-19.
7: Rivellese F, Manou-Stathopoulou S, Mauro D, Goldmann K, Pyne D, Rajakariar R, Gordon P, Schafer P, Bombardieri M, Pitzalis C, Lewis MJ. Effects of targeting the transcription factors Ikaros and Aiolos on B cell activation and differentiation in systemic lupus erythematosus Lupus Sci Med. 2021 Mar;8(1):e000445.
8: Bystrom J, Taher TE, Muhyaddin MS, Clanchy FI, Mangat P, Jawad AS, Williams RO, Mageed RA. Harnessing the Therapeutic Potential of Th17 Cells Mediators Inflamm. 2015;2015:205156.
9: Fedele PL, Willis SN, Liao Y, Low MS, Rautela J, Segal DH, Gong JN, Huntington ND, Shi W, Huang DCS, Grigoriadis G, Tellier J, Nutt SL. IMiDs prime myeloma cells for daratumumab-mediated cytotoxicity through loss of Ikaros and Aiolos Blood. 2018 Nov 15;132(20):2166-2178.
10: Abe Y, Ishida T. Immunomodulatory drugs in the treatment of multiple myeloma Jpn J Clin Oncol. 2019 Aug 1;49(8):695-702.

Products Related to Aiolos Antibody Monoclonal can be found at Antibodies