8-Hydroxy-2′-deoxyguanosine (8-Oxo-dG)

Product Description

8-Hydroxy-2′-deoxyguanosine (8-Oxo-dG)
Catalog number: B2010466
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 283.24
Supplied as: Powder
Appearance: Powder
Applications: highly pure (> 98%) 8-Oxo-dG with a wide array of applications in the study of DNA damage.
Storage: 2-8°C
Keywords: 8-Oxo-7,8-dihydro-2′-deoxyguanosine, 8-Oxo-dG
Grade: Biotechnology grade. All solid components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Pour Khavari A, Liu Y, He E, Skog S, Haghdoost S. Serum 8-Oxo-dG as a
Predictor of Sensitivity and Outcome of Radiotherapy and Chemotherapy of Upper
Gastrointestinal Tumours. Oxid Med Cell Longev. 2018 May 23;2018:4153574.

2: Haghdoost S, Svoboda P, Näslund I, Harms-Ringdahl M, Tilikides A, Skog S. Can
8-oxo-dG be used as a predictor for individual radiosensitivity? Int J Radiat
Oncol Biol Phys. 2001 Jun 1;50(2):405-10.

3: Karwowski BT. The Electronic Property Differences between dA::dG and
dA::dG^oxo. A Theoretical Approach. Molecules. 2020 Aug
23;25(17):3828.

4: Urbaniak SK, Boguszewska K, Szewczuk M, Kaźmierczak-Barańska J, Karwowski BT.
8-Oxo-7,8-Dihydro-2′-Deoxyguanosine (8-oxodG) and 8-Hydroxy-2′-Deoxyguanosine
(8-OHdG) as a Potential Biomarker for Gestational Diabetes Mellitus (GDM)
Development. Molecules. 2020 Jan 3;25(1):202.

5: Ceylan D, Yılmaz S, Tuna G, Kant M, Er A, Ildız A, Verim B, Akış M, Akan P,
İşlekel H, Veldic M, Frye M, Özerdem A. Alterations in levels of
8-Oxo-2′-deoxyguanosine and 8-Oxoguanine DNA glycosylase 1 during a current
episode and after remission in unipolar and bipolar depression.
Psychoneuroendocrinology. 2020 Apr;114:104600.

6: Hong IS, Greenberg MM. Sequence selective tagging of
8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo) using PNAs. Bioorg Med Chem
Lett. 2015 Nov 1;25(21):4918-4921.

7: O’Farrell NJ, Phelan JJ, Feighery R, Doyle B, Picardo SL, Ravi N, O’Toole D,
Reynolds JV, O’Sullivan J. Differential Expression Profiles of Oxidative Stress
Levels, 8-oxo-dG and 4-HNE, in Barrett’s Esophagus Compared to Esophageal
Adenocarcinoma. Int J Mol Sci. 2019 Sep 10;20(18):4449.

8: Espinosa O, Jiménez-Almazán J, Chaves FJ, Tormos MC, Clapes S, Iradi A,
Salvador A, Fandos M, Redón J, Sáez GT. Urinary
8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG), a reliable oxidative stress
marker in hypertension. Free Radic Res. 2007 May;41(5):546-54.

9: Haghdoost S, Czene S, Näslund I, Skog S, Harms-Ringdahl M. Extracellular
8-oxo-dG as a sensitive parameter for oxidative stress in vivo and in vitro.
Free Radic Res. 2005 Feb;39(2):153-62.
10: Kim JE, Hyun JW, Hayakawa H, Choi S, Choi J, Chung MH. Exogenous 8-oxo-dG is
not utilized for nucleotide synthesis but enhances the accumulation of 8-oxo-Gua
in DNA through error-prone DNA synthesis. Mutat Res. 2006 Apr
11;596(1-2):128-36.

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