6-Deoxy-6-(carboxymethylthio)-heptakis(6-deoxy-6-(2-carboxyethyl)thio)-gamma-cyclodextrin

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6-Deoxy-6-(carboxymethylthio)-heptakis(6-deoxy-6-(2-carboxyethyl)thio)-gamma-cyclodextrin
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6-Deoxy-6-(carboxymethylthio)-heptakis(6-deoxy-6-(2-carboxyethyl)thio)-gamma-cyclodextrin

Original price was: $1,795.00.Current price is: $895.00.

Catalog Number: B2027392 (100 mg)
6-Deoxy-6-(carboxymethylthio)-heptakis(6-deoxy-6-(2-carboxyethyl)thio)-gamma-cyclodextrin is a water-soluble, modified gamma-cyclodextrin derivative and single isomer structurally related to sugammadex. Available as a high-purity analytical standard (CODE: CY-3246), it features selective thioether modifications designed for laboratory reagent and biotechnology research applications. The compound is supplied in a slightly acidic powder form to maintain stability during storage. Custom bulk amounts of this product are available upon request.

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Product Description

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6-Deoxy-6-(carboxymethylthio)-heptakis(6-deoxy-6-(2-carboxyethyl)thio)-gamma-cyclodextrin
Catalog number: B2027392
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 mg
Molecular Weight or Concentration: NA
Supplied as: Chemicals
Storage: −80°C
Keywords: Sugammadex Impurity A, Sugammadex mono-carboxymethyl analogue

References:
1. Nagase, Y., et al. (2018). Development of Sugammadex Sodium and Its Clinical Applications. Chemical and Pharmaceutical Bulletin, 66(11), 1030-1036.
2. Bom, A., et al. (2002). A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a synthetic cyclodextrin derivative. Angewandte Chemie International Edition, 41(2), 265-270.
3. Adam, J. M., et al. (2002). Cyclodextrin derived host molecules for selective binding of neuromuscular blocking agents. Bioorganic & Medicinal Chemistry Letters, 12(18), 2603-2605.
4. Welliver, M. (2006). Sugammadex: A selective relaxant binding agent. AANA Journal, 74(2), 135-143.
5. Tarver, A. L., et al. (2009). Sugammadex: A novel agent for the reversal of neuromuscular blockade. Pharmacotherapy, 29(9), 1081-1090.
6. Gijsenbergh, F., et al. (2005). First human exposure of Org 25969, a novel agent for the reversal of rocuronium-induced neuromuscular blockade. Anesthesiology, 103(4), 695-703.
7. Zhang, M. Q. (2012). Drug-specific cyclodextrins: The story of sugammadex. Advanced Drug Delivery Reviews, 64(14), 1601-1610.
8. Suy, K., et al. (2007). Effective reversal of moderate rocuronium- or vecuronium-induced neuromuscular block with sugammadex. Anesthesiology, 106(2), 283-288.
9. Sacan, O., et al. (2007). Reversal of rocuronium-induced neuromuscular block with sugammadex is faster than reversal of cisatracurium-induced block with neostigmine. Anesthesiology, 107(2), 239-245.
10. Nicholson, W. T., et al. (2016). Sugammadex: A comprehensive review of its pharmacology, clinical efficacy, and safety profile. Journal of Clinical Anesthesia, 35, 520-529.
6-Deoxy-6-(carboxymethylthio)-heptakis(6-deoxy-6-(2-carboxyethyl)thio)-gamma-cyclodextrin

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Additional Information

Weight 0.15 oz
Dimensions 2 × 0.5 × 0.5 in
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