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390 MMP FRET Substrate 1

$595.00

Catalog Number: B2011209 (1 mg)
390 MMP FRET Substrate 1 is a high quality fluorogenic substrate for Matrix Metalloproteinases MMP-7, 8, 9 and 13. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

Live enquiry about this product via Text/SMS: 1-858-900-3210.

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SKU: B2011209 Categories: ,

Description

390 MMP FRET Substrate 1
Catalog number: B2011209
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 1093.2 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: 390 MMP FRET Substrate I
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Tranchant I, Vera L, Czarny B, Amoura M, Cassar E, Beau F, Stura EA, Dive V. Halogen bonding controls selectivity of FRET substrate probes for MMP-9 Chem Biol. 2014 Mar 20;21(3):408-13.
2: Lauer-Fields JL, Minond D, Chase PS, Baillargeon PE, Saldanha SA, Stawikowska R, Hodder P, Fields GB. High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate Bioorg Med Chem. 2009 Feb 1;17(3):990-1005.
3: Ji X , Xie S , Jiao Y , Zhang X , Sun D , Yang VC , Wang M , He H , Sun L . MT1-MMP activatable fluorogenic probes with enhanced specificity via high-affinity peptide conjugation for tumor imaging Biomater Sci. 2020 Apr 21;8(8):2308-2317.
4: Pahwa S, Bhowmick M, Amar S, Cao J, Strongin AY, Fridman R, Weiss SJ, Fields GB. Characterization and regulation of MT1-MMP cell surface-associated activity Chem Biol Drug Des. 2019 Jun;93(6):1251-1264.
5: Meyer BS, Rademann J. Extra- and intracellular imaging of human matrix metalloprotease 11 (hMMP-11) with a cell-penetrating FRET substrate J Biol Chem. 2012 Nov 2;287(45):37857-67.
6: Yang J, Zhang Z, Lin J, Lu J, Liu BF, Zeng S, Luo Q. Detection of MMP activity in living cells by a genetically encoded surface-displayed FRET sensor Biochim Biophys Acta. 2007 Mar;1773(3):400-7.
7: Giricz O, Lauer JL, Fields GB. Comparison of metalloproteinase protein and activity profiling Anal Biochem. 2011 Feb 1;409(1):37-45.
8: Stawikowski MJ, Knapinska AM, Fields GB. Determining the Substrate Specificity of Matrix Metalloproteases using Fluorogenic Peptide Substrates Methods Mol Biol. 2017;1579:137-183.
9: Tokmina-Roszyk M, Fields GB. Dissecting MMP P(10)’ and P(11)’ subsite sequence preferences, utilizing a positional scanning, combinatorial triple-helical peptide library J Biol Chem. 2018 Oct 26;293(43):16661-16676.
10: Lei Z, Zhang H, Wang Y, Meng X, Wang Z. Peptide Microarray-Based Metal Enhanced Fluorescence Assay for Multiple Profiling of Matrix Metalloproteinases Activities Anal Chem. 2017 Jun 20;89(12):6749-6757.

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