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1,5-Dansyl-Glu-Gly-Arg Chloromethyl Ketone

$495.00

Catalog Number: B2010255 (5 mg)
1,5-Dansyl-Glu-Gly-Arg Chloromethyl Ketone Dihydrochloride is a high quality research product used as high purity effective irreversible inhibitor of uPA, Factor Xa, and urokinase (does not inhibit tPA). The presence of a fluorofore conviniently allows the monitoring of molecular interactions. Custom bulk orders of this product are available upon request.

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SKU: B2010255 Categories: , ,

Description

1,5-Dansyl-Glu-Gly-Arg Chloromethyl Ketone Dihydrochloride
Catalog number: B2010255
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 5 mg
pH: n/a
Supplied as: Reconstitute before use
Appearance: Solid
Applications: high purity effective irreversible inhibitor of uPA, Factor Xa, and urokinase (does not inhibit tPA). The presence of a fluorofore conviniently allows the monitoring of molecular interactions.
Storage: -20C
Keywords: 1,5-DNS-GGACK, 2HCl
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through0.22 um.

References:
1: Lyon ME, Drobot DW, Harding SR, Lyon AW. Evaluation of the thrombin inhibitor
D-phenylalanyl-L-prolyl-L-arginine chloromethylketone (PPACK) with the factor Xa
inhibitor 1,5-dansyl-L-glutamyl-L-glycyl-L-arginine chloromethylketone (GGACK)
as anticoagulants for critical care clinical chemistry specimens. Clin Chim
Acta. 1999 Feb;280(1-2):91-9.

2: Kemball-Cook G, Johnson DJ, Tuddenham EG, Harlos K. Crystal structure of
active site-inhibited human coagulation factor VIIa (des-Gla). J Struct Biol.
1999 Oct;127(3):213-23.

3: Hohsaka T, Muranaka N, Komiyama C, Matsui K, Takaura S, Abe R, Murakami H,
Sisido M. Position-specific incorporation of dansylated non-natural amino acids
into streptavidin by using a four-base codon. FEBS Lett. 2004 Feb
27;560(1-3):173-7.

4: Norstrøm EA, Tran S, Steen M, Dahlbäck B. Effects of factor Xa and protein S
on the individual activated protein C-mediated cleavages of coagulation factor
Va. J Biol Chem. 2006 Oct 20;281(42):31486-94.

5: Marrakchi S, Maibach HI. Functional map and age-related differences in the
human face: nonimmunologic contact urticaria induced by hexyl nicotinate.
Contact Dermatitis. 2006 Jul;55(1):15-9.

6: Hu CK, Kohnert U, Wilhelm O, Fischer S, Llinás M. Tissue-type plasminogen
activator domain-deletion mutant BM 06.022: modular stability, inhibitor
binding, and activation cleavage. Biochemistry. 1994 Oct 4;33(39):11760-6.

7: Burtnick LD, Bhangu K. Interaction of actin with dansyl-tropomyosin. FEBS
Lett. 1986 Mar 31;198(2):307-10.

8: Johannesson A, Hammar H. Measurement of the horny layer turnover after
staining with dansyl chloride: description of a new method. Acta Derm Venereol.
1978;58(1):76-9.

9: Camerer E, Rottingen JA, Iversen JG, Prydz H. Coagulation factors VII and X
induce Ca2+ oscillations in Madin-Darby canine kidney cells only when
proteolytically active. J Biol Chem. 1996 Nov 15;271(46):29034-42.

Johnson DJ, Nugent PG, Tuddenham EG, Harlos K, Kemball-Cook G.
Crystallization and preliminary X-ray analysis of active site-inhibited human
coagulation factor VIIa (des-Gla). J Struct Biol. 1999 Mar;125(1):90-3.

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