Catalog Number: B2010427 (100 mg)
1,2-Distearoyl-sn-glycero-3-phosphocholine is a high quality research product used as A high purity 1,2-Distearoyl-sn-glycero-3-phosphocholine used as well-defined liposomes with a wide array of applications in biochemistry and cellular biology. Custom bulk orders of this product are available upon request.
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SKU: B2010427 Categories: , ,


Catalog number: B2010427
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 mg
Molecular Weight or Concentration: 790.15
Supplied as: Powder
Appearance: Powder
Applications: A high purity 1,2-Distearoyl-sn-glycero-3-phosphocholine used as well-defined liposomes with a wide array of applications in biochemistry and cellular biology.
Storage: -20C
Keywords: PC(18:0/18:0), 3-sn-Phosphatidylcholine, 1,2-distearoyl, 1,2-Dioctadecanoyl-sn-glycero-3-phosphocholine, PC, DSPC, L-β,γ-Distearoyl-α-lecithin, L-α-Phosphatidylcholine, distearoyl
Grade: Biotechnology grade. All solid components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Norling K, Bernasconi V, Agmo Hernández V, Parveen N, Edwards K, Lycke NY,
Höök F, Bally M. Gel Phase 1,2-Distearoyl-sn-glycero-3-phosphocholine-
Based Liposomes Are Superior to Fluid Phase Liposomes at Augmenting Both Antigen
Presentation on Major Histocompatibility Complex Class II and Costimulatory
Molecule Display by Dendritic Cells in Vitro. ACS Infect Dis. 2019 Nov

2: Dabkowska AP, Barlow DJ, Clifton LA, Hughes AV, Webster JR, Green RJ, Quinn
PJ, Lawrence MJ. Calcium-mediated binding of DNA to 1,2-distearoyl-sn-
glycero-3-phosphocholine-containing mixed lipid monolayers. Soft Matter. 2014
Mar 21;10(11):1685-95.

3: Smith MC, Crist RM, Clogston JD, McNeil SE. Zeta potential: a case study of
cationic, anionic, and neutral liposomes. Anal Bioanal Chem. 2017

4: Ponpipom MM, Bugianesi RL. Isolation of 1,3-distearoyl-
glycero-2-phosphocholine (beta-lecithin) from commercial 1,2-distearoyl-sn-
glycero-3-phosphocholine. J Lipid Res. 1980 Jan;21(1):136-9.

5: Tien Sing Young RV, Tabrizian M. Rapid, one-step fabrication and loading of
nanoscale 1,2-distearoyl-sn-glycero-3-phosphocholine liposomes in a simple,
double flow-focusing microfluidic device. Biomicrofluidics. 2015 Jul

6: Briuglia ML, Rotella C, McFarlane A, Lamprou DA. Influence of cholesterol on
liposome stability and on in vitro drug release. Drug Deliv Transl Res. 2015

7: Santaren JF, Rico M, Guilleme J, Ribera A. Thermal and 13C-NMR study of the
dynamic structure of 1-palmitoyl-2-oleyl-sn-glycero-3-phosphocholine and
1-oleyl-2-palmitoyl-sn-glycero-3-phosphocholine in aqueous dispersions. Biochim
Biophys Acta. 1982 May 7;687(2):231-7.

8: Erdoğ A, Putra Limasale YD, Keskin D, Tezcaner A, Banerjee S. In vitro
characterization of a liposomal formulation of celecoxib containing
1,2-distearoyl-sn-glycero-3-phosphocholine, cholesterol, and polyethylene glycol
and its functional effects against colorectal cancer cell lines. J Pharm Sci.
2013 Oct;102(10):3666-77.

9: Hussain MJ, Wilkinson A, Bramwell VW, Christensen D, Perrie Y. Th1 immune
responses can be modulated by varying dimethyldioctadecylammonium and
distearoyl-sn-glycero-3-phosphocholine content in liposomal adjuvants. J Pharm
Pharmacol. 2014 Mar;66(3):358-66.
10: Kulkarni JA, Darjuan MM, Mercer JE, Chen S, van der Meel R, Thewalt JL, Tam
YYC, Cullis PR. On the Formation and Morphology of Lipid Nanoparticles
Containing Ionizable Cationic Lipids and siRNA. ACS Nano. 2018 May

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