11β-HSD1 HDR Plasmid

Product Description

11β-HSD1 HDR Plasmid
Catalog number: B2015202
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 µg
Molecular Weight or Concentration: N/A
Supplied as: Solution
Applications: a molecular tool for various biochemical applications
Storage: 2 – 8 °C
Keywords: 11β-HSD1 HDR Plasmid
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
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2: Singh R, Bhardwaj VK, Das P, Purohit R. Identification of 11β-HSD1 inhibitors through enhanced sampling methods Chem Commun (Camb). 2022 Apr 19;58(32):5005-5008.
3: Hale C, Wang M. Development of 11beta-HSD1 inhibitors for the treatment of type 2 diabetes Mini Rev Med Chem. 2008 Jun;8(7):702-10.
4: Li X, Qiu W, Deng L, Lin J, Huang W, Xu Y, Zhang M, Jones NC, Lin R, Xu H, Lin L, Li P, Wang X. 11β-HSD1 participates in epileptogenesis and the associated cognitive impairment by inhibiting apoptosis in mice J Transl Med. 2022 Sep 5;20(1):406.
5: Fang CH, Li YP, Li Y, Yue JM, Bao J, Yu JH. Triterpenoids with multi-skeletons as 11 β -HSD1 inhibitors from Euphorbia sikkimensis Phytochemistry. 2023 Jul;211:113684.
6: Chen Y, Li J, Zhang M, Yang W, Qin W, Zheng Q, Chu Y, Wu Y, Wu D, Yuan X. 11β-HSD1 Inhibitor Alleviates Non-Alcoholic Fatty Liver Disease by Activating the AMPK/SIRT1 Signaling Pathway Nutrients. 2022 Jun 6;14(11):2358.
7: Odermatt A, Atanasov AG, Balazs Z, Schweizer RA, Nashev LG, Schuster D, Langer T. Why is 11beta-hydroxysteroid dehydrogenase type 1 facing the endoplasmic reticulum lumen? Physiological relevance of the membrane topology of 11beta-HSD1 Mol Cell Endocrinol. 2006 Mar 27;248(1-2):15-23.
8: Westgate CSJ, Markey K, Mitchell JL, Yiangou A, Singhal R, Stewart P, Tomlinson JW, Lavery GG, Mollan SP, Sinclair AJ. Increased systemic and adipose 11β-HSD1 activity in idiopathic intracranial hypertension Eur J Endocrinol. 2022 Jul 4;187(2):323-333.
9: Harno E, White A. Will treating diabetes with 11β-HSD1 inhibitors affect the HPA axis? Trends Endocrinol Metab. 2010 Oct;21(10):619-27.
10: Gathercole LL, Lavery GG, Morgan SA, Cooper MS, Sinclair AJ, Tomlinson JW, Stewart PM. 11β-Hydroxysteroid dehydrogenase 1: translational and therapeutic aspects Endocr Rev. 2013 Aug;34(4):525-55.

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