11β-HSD1 Double Nickase Plasmid

Product Description

11β-HSD1 Double Nickase Plasmid
Catalog number: B2015146
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 µg
Molecular Weight or Concentration: N/A
Supplied as: Powder
Applications: a molecular tool for various biochemical applications
Storage: 2-8 °C
Keywords: 11β-HSD1 Double Nickase Plasmid
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Tomlinson JW. 11Beta-hydroxysteroid dehydrogenase type 1 in human disease: a novel therapeutic target Minerva Endocrinol. 2005 Mar;30(1):37-46.
2: Yan H, Li X, Ni W, Zhao Q, Leng Y, Liu HY. Phytochemicals from the Leaves of Cyclocarya paliurus and their 11β-HSD1 Enzyme Inhibitory Effects Chem Biodivers. 2021 Jan;18(1):e2000772.
3: Lee NR, Kim BJ, Lee CH, Lee YB, Lee S, Hwang HJ, Kim E, Kim SH, Lee MG, Lee SE, Lavery GG, Choi EH. Role of 11β-hydroxysteroid dehydrogenase type 1 in the development of atopic dermatitis Sci Rep. 2020 Nov 19;10(1):20237.
4: Staab CA, Maser E. 11beta-Hydroxysteroid dehydrogenase type 1 is an important regulator at the interface of obesity and inflammation J Steroid Biochem Mol Biol. 2010 Mar;119(1-2):56-72.
5: Osman DA, Macías MA, Al-Wahaibi LH, Al-Shaalan NH, Zondagh LS, Joubert J, Garcia-Granda S, El-Emam AA. Structural Insights and Docking Analysis of Adamantane-Linked 1,2,4-Triazole Derivatives as Potential 11β-HSD1 Inhibitors Molecules. 2021 Sep 2;26(17):5335.
6: Chapman KE, Coutinho A, Gray M, Gilmour JS, Savill JS, Seckl JR. Local amplification of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1 and its role in the inflammatory response Ann N Y Acad Sci. 2006 Nov;1088:265-73.
7: Hadoke PW, Kipari T, Seckl JR, Chapman KE. Modulation of 11β-hydroxysteroid dehydrogenase as a strategy to reduce vascular inflammation Curr Atheroscler Rep. 2013 May;15(5):320.
8: Gathercole LL, Stewart PM. Targeting the pre-receptor metabolism of cortisol as a novel therapy in obesity and diabetes J Steroid Biochem Mol Biol. 2010 Oct;122(1-3):21-7.
9: Shao LD, Bao Y, Shen Y, Su J, Leng Y, Zhao QS. Synthesis of selective 11β-HSD1 inhibitors based on dammarane scaffold Eur J Med Chem. 2017 Jul 28;135:324-338.
10: Seckl JR, Walker BR. 11beta-hydroxysteroid dehydrogenase type 1 as a modulator of glucocorticoid action: from metabolism to memory Trends Endocrinol Metab. 2004 Nov;15(9):418-24.

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