1-Methyl-2-pyrrolidinone

Product Description

1-Methyl-2-pyrrolidinone
Catalog number: B2014994
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 100 mL
Molecular Weight or Concentration: 99.13
Supplied as: Liquid
Applications: molecular tool for various biochemical applications
Storage: RT
Keywords: 1-Methyl-2-pyrrolidone, N-Methyl-2-pyrrolidone, NMP
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Thackaberry EA, Wang X, Schweiger M, Messick K, Valle N, Dean B, Sambrone A, Bowman T, Xie M. Solvent-based formulations for intravenous mouse pharmacokinetic studies: tolerability and recommended solvent dose limits Xenobiotica. 2014 Mar;44(3):235-41.
2: Mayer VW, Goin CJ, Taylor-Mayer RE. Aneuploidy induction in Saccharomyces cerevisiae by two solvent compounds, 1-methyl-2-pyrrolidinone and 2-pyrrolidinone Environ Mol Mutagen. 1988;11(1):31-40.
3: Workplace environmental exposure level guide: n-Methyl-2-pyrrolidone Toxicol Ind Health. 2022 Jun;38(6):309-329.
4: Hilton-Proctor JP, Ilyichova O, Zheng Z, Jennings IG, Johnstone RW, Shortt J, Mountford SJ, Scanlon MJ, Thompson PE. Substituted 1-methyl-4-phenylpyrrolidin-2-ones – Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors Eur J Med Chem. 2020 Apr 1;191:112120.
5: Engelhardt G, Fleig H. 1-Methyl-2-pyrrolidinone (NMP) does not induce structural and numerical chromosomal aberrations in vivo Mutat Res. 1993 Jan;298(3):149-55.
6: Jung DW, Yang DA, Kim J, Kim J, Ahn WS. Facile synthesis of MOF-177 by a sonochemical method using 1-methyl-2-pyrrolidinone as a solvent Dalton Trans. 2010 Mar 21;39(11):2883-7.
7: Liu Y, Ji Y, Chen J, Chen X, Wang G, Shang Y, Liu X, Pan J. Validated hydrophilic interaction LC-MS/MS method for determination of N-methyl-2-pyrrolidinone residue: Applied to a depletion study of N-methyl-2-pyrrolidinone in swine liver following intramuscular administration of drug N-methyl-2-pyrrolidinone formulation J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Dec 1;878(31):3283-9.
8: Midgley I, Hood AJ, Chasseaud LF, Brindley CJ, Baughman S, Allan G. Percutaneous absorption of co-administered N-methyl-2-[14C]pyrrolidinone and 2-[14C]pyrrolidinone in the rat Food Chem Toxicol. 1992 Jan;30(1):57-64.
9: Zhou Q, Hambley TW, Kennedy BJ, Lay PA, Turner P, Warwick B, Biffin JR, Regtop HL. Syntheses and characterization of anti-inflammatory dinuclear and mononuclear zinc indomethacin complexes. Crystal structures of [Zn2(indomethacin)4(L)2] (L = N,N-dimethylacetamide, pyridine, 1-methyl-2-pyrrolidinone) and [Zn(indomethacin)2(L1)2] (L1 = ethanol, methanol) Inorg Chem. 2000 Aug 21;39(17):3742-8.
10: Meier S, Schindler BK, Koslitz S, Koch HM, Weiss T, Käfferlein HU, Brüning T. Biomonitoring of exposure to N-methyl-2-pyrrolidone in workers of the automobile industry Ann Occup Hyg. 2013 Jul;57(6):766-73.

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