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A new interesting article has been published in J Clin Pathol. 2019 Dec; 72(12):825-829. doi: 10.1136/jclinpath-2019-205700. Epub 2019 Jun 24. and titled:

Feasibility of combined screening for upper gastrointestinal adenocarcinoma risk by serology and Cytosponge testing: the SUGAR study.

Authors of this article are:

Xu Y, Miremadi A, Link A, Malfertheiner P, Fitzgerald RC, Bornschein J.

A summary of the article is shown below:

AIMS: Aim was to assess the feasibility of serum markers to identify individuals at risk for gastro-oesophageal adenocarcinoma to reduce the number of individuals requiring invasive assessment by endoscopy.METHODS: Blood samples from 56 patients with Barrett’s oesophagus and 202 non-Barrett controls who previously took part in a trial assessing the accuracy of the Cytosponge for Barrett’s oesophagus were assessed for serum pepsinogen (PG) 1 and 2, gastrin-17, trefoil factor 3 (TFF3) and Helicobacter pylori infection.RESULTS: PG1 was pathological (<50 ng/mL) in 26 patients (10.1%), none of whom had Barrett's oesophagus (p<0.001). Smoking and drinking had no influence on these results. Pathological PG1 was associated with stomach pain (p=0.029), disruption of sleep (p=0.027) and disruption of diet by symptoms (p=0.019). Serum TFF3 was not associated with any clinical parameter.CONCLUSIONS: Assessment of serum PG1 could be combined with a test for Barrett's oesophagus to identify additional patients requiring endoscopy.© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.
Check out the article’s website on Pubmed for more information:

[link-preview url=https://www.ncbi.nlm.nih.gov/pubmed/31235543 forceshot=true]

This article is a good source of information and a good way to become familiar with topics such as: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Barrett Esophagus; Biomarkers, Tumor; Case-Control Studies; Early Detection of Cancer; Esophageal Neoplasms; Feasibility Studies; Female; Humans; Male; Middle Aged; Pepsinogen A; Pepsinogen C; Predictive Value of Tests; Prognosis; Reproducibility of Results; Risk Assessment; Risk Factors; Stomach Neoplasms; Trefoil Factor-3; Young Adult.

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