WWP1 Active Human Protein

Description

WWP1 Active Human Protein
Catalog number: B2014063
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 20 μg
Molecular Weight or Concentration: 106 kDa
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: AIP5, Atrophin-1 interacting protein 5, NEDD4-like E3 ubiquitin-protein ligase, TGIF-interacting ubiquitin ligase 1 (Tiul1), WW domain containing E3 ubiquitin protein ligase 1
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Lee YR, Yehia L, Kishikawa T, Ni Y, Leach B, Zhang J, Panch N, Liu J, Wei W, Eng C, Pandolfi PP. WWP1 Gain-of-Function Inactivation of PTEN in Cancer Predisposition N Engl J Med. 2020 May 28;382(22):2103-2116.
2: Lee YR, Chen M, Lee JD, Zhang J, Lin SY, Fu TM, Chen H, Ishikawa T, Chiang SY, Katon J, Zhang Y, Shulga YV, Bester AC, Fung J, Monteleone E, Wan L, Shen C, Hsu CH, Papa A, Clohessy JG, Teruya-Feldstein J, Jain S, Wu H, Matesic L, Chen RH, Wei W, Pandolfi PP. Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway Science. 2019 May 17;364(6441):eaau0159.
3: Kishikawa T, Higuchi H, Wang L, Panch N, Maymi V, Best S, Lee S, Notoya G, Toker A, Matesic LE, Wulf GM, Wei W, Otsuka M, Koike K, Clohessy JG, Lee YR, Pandolfi PP. WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models J Clin Invest. 2021 Dec 15;131(24):e140436.
4: Yu JJ, Zhou DD, Yang XX, Cui B, Tan FW, Wang J, Li K, Shang S, Zhang C, Lv XX, Zhang XW, Liu SS, Yu JM, Wang F, Huang B, Hua F, Hu ZW. TRIB3-EGFR interaction promotes lung cancer progression and defines a therapeutic target Nat Commun. 2020 Jul 21;11(1):3660.
5: Wang L, Zhou Y, Jiang L, Lu L, Dai T, Li A, Chen Y, Zhang L. CircWAC induces chemotherapeutic resistance in triple-negative breast cancer by targeting miR-142, upregulating WWP1 and activating the PI3K/AKT pathway Mol Cancer. 2021 Mar 1;20(1):43.
6: Zhang Q, Huang AZ, Shen FJ, Yu JP, Qin CZ. [WWP1 promotes cell proliferation in hepatocellular carcinoma through ubiquitin-degradation EI24] Zhonghua Zhong Liu Za Zhi. 2020 Mar 23;42(3):203-209.
7: Flasza M, Nguyen Huu NS, Mazaleyrat S, Clmence S, Villemant C, Clarke R, Baron M. Regulation of the nuclear localization of the human Nedd4-related WWP1 protein by Notch Mol Membr Biol. 2006 May-Jun;23(3):269-76.
8: Zhao P, Wang M, An J, Sun H, Li T, Li D. A positive feedback loop of miR-30a-5p-WWP1-NF-B in the regulation of glioma development Int J Biochem Cell Biol. 2019 Jul;112:39-49.
9: Zhou Z, Liu R, Chen C. The WWP1 ubiquitin E3 ligase increases TRAIL resistance in breast cancer Int J Cancer. 2012 Apr 1;130(7):1504-10.
10: Chen C, Zhou Z, Ross JS, Zhou W, Dong JT. The amplified WWP1 gene is a potential molecular target in breast cancer Int J Cancer. 2007 Jul 1;121(1):80-87.

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