Thrombin-Sensitive Peptide

Product Description

Thrombin-Sensitive Peptide
Catalog number: B2012607
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 2,143.0 g/mol
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: ThS-P
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Tanihara M, Suzuki Y, Nishimura Y, Suzuki K, Kakimaru Y. Thrombin-sensitive peptide linkers for biological signal-responsive drug release systems Peptides. 1998;19(3):421-5.
2: Feng J, Zhuo C, Ma X, Li S, Zhang Y. A peptide with a cysteine terminus: probe for label-free fluorescent detection of thrombin activity Analyst. 2016 Jul 21;141(14):4481-7.
3: Münzer P, Tolios A, Pelzl L, Schmid E, Schmidt EM, Walker B, Fröhlich H, Borst O, Gawaz M, Lang F. Thrombin-sensitive expression of the store operated Ca(2+) channel Orai1 in platelets Biochem Biophys Res Commun. 2013 Jun 21;436(1):25-30.
4: Gabriel D, Lange N, Chobaz-Peclat V, Zuluaga MF, Gurny R, van den Bergh H, Busso N. Thrombin-sensitive dual fluorescence imaging and therapeutic agent for detection and treatment of synovial inflammation in murine rheumatoid arthritis J Control Release. 2012 Oct 28;163(2):178-86.
5: Gabriel D, Busso N, So A, van den Bergh H, Gurny R, Lange N. Thrombin-sensitive photodynamic agents: a novel strategy for selective synovectomy in rheumatoid arthritis J Control Release. 2009 Sep 15;138(3):225-34.
6: Leung DT, Lim PL, Cheung TH, Wong RR, Yim SF, Ng MH, Tam FC, Chung TK, Wong YF. Osteopontin Fragments with Intact Thrombin-Sensitive Site Circulate in Cervical Cancer Patients PLoS One. 2016 Aug 5;11(8):e0160412.
7: Borgel D, Gaussem P, Garbay C, Bachelot-Loza C, Kaabache T, Liu WQ, Brohard-Bohn B, Le Bonniec B, Aiach M, Gandrille S. Implication of protein S thrombin-sensitive region with membrane binding via conformational changes in the gamma-carboxyglutamic acid-rich domain Biochem J. 2001 Dec 1;360(Pt 2):499-506.
8: Van de Vijver P, Schmitt M, Suylen D, Scheer L, Thomassen MC, Schurgers LJ, Griffin JH, Koenen RR, Hackeng TM. Incorporation of disulfide containing protein modules into multivalent antigenic conjugates: generation of antibodies against the thrombin-sensitive region of murine protein S J Am Chem Soc. 2012 Nov 28;134(47):19318-21.
9: Wang Y, Xu M, Yang N, Gao S, Li S, Zhang J, Bi Y, Ren S, Hou Y, Jiang M, Liu J, Hu Y, Gao L, Cao F. A Thrombin-Responsive Nanoprobe for In Vivo Visualization of Thrombus Formation through Three-Dimensional Optical/Computed Tomography Hybrid Imaging ACS Appl Mater Interfaces. 2021 Jun 23;13(24):27814-27824.
10: Welsh JD, Colace TV, Muthard RW, Stalker TJ, Brass LF, Diamond SL. Platelet-targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse J Thromb Haemost. 2012 Nov;10(11):2344-53.

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