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Siastatin B (Highly Pure)

$295.00

Catalog Number: MDP0888 (1 mg)
Siastatin B is a highly pure inhibitor of sialidase. This product has been used as glycosidase Inhibitor. It has also been used in a wide array of other biochemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Description

Siastatin B
Catalog number: MDP0888
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 218.21 g/mol
Supplied as: Powder
Applications: glycosidase Inhibitor
Storage: 2-8°C
Keywords: (3S,4S,5R,6R)-6-(Acetylamino)-4,5-Dihydroxy-3-Piperidinecarboxylic Acid
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.
Indication for Use:This product is for Research Use Only. This product is NOT for human or animal use.

References:
1: Rahman MM, Hirokawa T, Tsuji D, Tsukimoto J, Hitaoka S, Yoshida T, Chuman H,
Itoh K. Novel pH-dependent regulation of human cytosolic sialidase 2 (NEU2)
activities by siastatin B and structural prediction of NEU2/siastatin B complex.
Biochem Biophys Rep. 2015 Sep 25;4:234-242.

2: Knapp S, Zhao D. Synthesis of the sialidase inhibitor siastatin_B. Org Lett.
2000 Dec 14;2(25):4037-40.

3: Satoh T, Nishimura Y, Kondo S, Takeuchi T. A practical synthesis from
siastatin_B of (3S,4S,5R,6R)-
4,5-dihydroxy-6-(trifluoroacetamido)piperidine-3-carboxylic acid having
antimetastatic activity in mice. Carbohydr Res. 1996 Jun 5;286:173-8.

4: Nishimura Y, Satoh T, Kudo T, Kondo S, Takeuchi T. Synthesis and activity of
1-N-iminosugar inhibitors, siastatin_B analogues for alpha-N-
acetylgalactosaminidase and beta-N-acetylglucosaminidase. Bioorg Med Chem. 1996
Jan;4(1):91-6.

5: Kudo T, Nishimura Y, Kondo S, Takeuchi T. Syntheses and activities of
N-substituted derivatives of siastatin_B. J Antibiot (Tokyo). 1992
Oct;45(10):1662-8.

6: Nishimura Y, Kudo T, Kondo S, Takeuchi T, Tsuruoka T, Fukuyasu H, Shibahara
S. Totally synthetic analogues of siastatin B. III. Trifluoroacetamide analogues
having inhibitory activity for tumor metastasis. J Antibiot (Tokyo). 1994
Jan;47(1):101-7.

7: Nishimura Y, Kudo T, Kondo S, Takeuchi T. Totally synthetic analogues of
siastatin B. II. Optically active piperidine derivatives having
trifluoroacetamide and hydroxyacetamide groups at C-2. J Antibiot (Tokyo). 1992
Jun;45(6):963-70.

8: Nishimura Y, Umezawa Y, Kondo S, Takeuchi T, Mori K, Kijima-Suda I, Tomita K,
Sugawara K, Nakamura K. Synthesis of 3-episiastatin B analogues having anti-
influenza virus activity. J Antibiot (Tokyo). 1993 Dec;46(12):1883-9.

9: Satoh T, Nishimura Y, Kondo S, Takeuchi T, Azetaka M, Fukuyasu H, Iizuka Y,
Ohuchi S, Shibahara S. Synthesis and antimetastatic activity of
6-trichloroacetamido and 6-guanidino analogues of siastatin B. J Antibiot
(Tokyo). 1996 Mar;49(3):321-5.
10: Kudo T, Nishimura Y, Kondo S, Takeuchi T. Syntheses of the potent inhibitors
of neuraminidase, N-(1,2-dihydroxypropyl) derivatives of siastatin B and its
4-deoxy analogs. J Antibiot (Tokyo). 1993 Feb;46(2):300-9.

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