[Sar1, Ile4,8]-Angiotensin II

Product Description

[Sar1, Ile4,8]-Angiotensin II
Catalog number: MDP0830
CAS Number: 147157-97-9
Sequence: Sar-Arg-Val-Ile-Ile-His-Pro-Ile
Amount: 500 ug
Molecular Weight: 918 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Sanni SJ, Lyngsø C, Gammeltoft S, Hansen JL. [Sar1, Ile4, Ile8]-angiotensin II Potentiates Insulin Receptor Signalling and Glycogen Synthesis in Hepatocytes Basic Clin Pharmacol Toxicol. 2018 May;122(5):460-469.
2: Wilson PC, Lee MH, Appleton KM, El-Shewy HM, Morinelli TA, Peterson YK, Luttrell LM, Jaffa AA. The arrestin-selective angiotensin AT1 receptor agonist [Sar1,Ile4,Ile8]-AngII negatively regulates bradykinin B2 receptor signaling via AT1-B2 receptor heterodimers J Biol Chem. 2013 Jun 28;288(26):18872-84.
3: Kendall RT, Strungs EG, Rachidi SM, Lee MH, El-Shewy HM, Luttrell DK, Janech MG, Luttrell LM. The beta-arrestin pathway-selective type 1A angiotensin receptor (AT1A) agonist [Sar1,Ile4,Ile8]angiotensin II regulates a robust G protein-independent signaling network J Biol Chem. 2011 Jun 3;286(22):19880-91.
4: Miura S, Zhang J, Matsuo Y, Saku K, Karnik SS. Activation of extracellular signal-activated kinase by angiotensin II-induced Gq-independent epidermal growth factor receptor transactivation Hypertens Res. 2004 Oct;27(10):765-70.
5: Sánchez-Fernández G, Cabezudo S, García-Hoz C, Tobin AB, Mayor F Jr, Ribas C. ERK5 activation by Gq-coupled muscarinic receptors is independent of receptor internalization and β-arrestin recruitment PLoS One. 2013 Dec 17;8(12):e84174.
6: Sakai H, Matsuura K, Tanaka Y, Honda T, Nishida T, Inui M. Signaling mechanism underlying the promotion of keratinocyte migration by angiotensin II Mol Pharmacol. 2015 Feb;87(2):277-85.
7: Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villén J, Haas W, Kovacs JJ, Shukla AK, Hara MR, Hernandez M, Lachmann A, Zhao S, Lin Y, Cheng Y, Mizuno K, Ma’ayan A, Gygi SP, Lefkowitz RJ. Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR) Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15299-304.
8: Simard E, Kovacs JJ, Miller WE, Kim J, Grandbois M, Lefkowitz RJ. β-Arrestin regulation of myosin light chain phosphorylation promotes AT1aR-mediated cell contraction and migration PLoS One. 2013 Nov 8;8(11):e80532.
9: Christensen GL, Kelstrup CD, Lyngsø C, Sarwar U, Bøgebo R, Sheikh SP, Gammeltoft S, Olsen JV, Hansen JL. Quantitative phosphoproteomics dissection of seven-transmembrane receptor signaling using full and biased agonists Mol Cell Proteomics. 2010 Jul;9(7):1540-53.
10: Daniels D, Yee DK, Faulconbridge LF, Fluharty SJ. Divergent behavioral roles of angiotensin receptor intracellular signaling cascades Endocrinology. 2005 Dec;146(12):5552-60.

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