S3 Fragment ADF/cofilin LIMK1 Substrate

Product Description

S3 Fragment ADF/cofilin LIMK1 Substrate
Catalog number: B2011488
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 1698.1 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: S3 Fragment, ADF/cofilin, LIMK1 substrate
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Hamill S, Lou HJ, Turk BE, Boggon TJ. Structural Basis for Noncanonical Substrate Recognition of Cofilin/ADF Proteins by LIM Kinases Mol Cell. 2016 May 5;62(3):397-408.
2: Manetti F. LIM kinases are attractive targets with many macromolecular partners and only a few small molecule regulators Med Res Rev. 2012 Sep;32(5):968-98.
3: Salvarezza SB, Deborde S, Schreiner R, Campagne F, Kessels MM, Qualmann B, Caceres A, Kreitzer G, Rodriguez-Boulan E. LIM kinase 1 and cofilin regulate actin filament population required for dynamin-dependent apical carrier fission from the trans-Golgi network Mol Biol Cell. 2009 Jan;20(1):438-51.
4: Ritchey L, Ottman R, Roumanos M, Chakrabarti R. A functional cooperativity between Aurora A kinase and LIM kinase1: implication in the mitotic process Cell Cycle. 2012 Jan 15;11(2):296-309.
5: Chatterjee D, Preuss F, Dederer V, Knapp S, Mathea S. Structural Aspects of LIMK Regulation and Pharmacology Cells. 2022 Jan 2;11(1):142.
6: Pandey D, Goyal P, Bamburg JR, Siess W. Regulation of LIM-kinase 1 and cofilin in thrombin-stimulated platelets Blood. 2006 Jan 15;107(2):575-83.
7: Mashiach-Farkash E, Rak R, Elad-Sfadia G, Haklai R, Carmeli S, Kloog Y, Wolfson HJ. Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton Oncotarget. 2012 Jun;3(6):629-39.
8: Wang W, Mouneimne G, Sidani M, Wyckoff J, Chen X, Makris A, Goswami S, Bresnick AR, Condeelis JS. The activity status of cofilin is directly related to invasion, intravasation, and metastasis of mammary tumors J Cell Biol. 2006 May 8;173(3):395-404.
9: Petrilli A, Copik A, Posadas M, Chang LS, Welling DB, Giovannini M, Fernández-Valle C. LIM domain kinases as potential therapeutic targets for neurofibromatosis type 2 Oncogene. 2014 Jul 3;33(27):3571-82.
10: Antonipillai J, Mittelstaedt K, Rigby S, Bassler N, Bernard O. LIM kinase 2 (LIMK2) may play an essential role in platelet function Exp Cell Res. 2020 Mar 1;388(1):111822.

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