Renin Substrate 1


Catalog Number: B2012897 (1 mg)
Renin Substrate 1 is a high quality substrate for human renin, an aspartic protease which plays an important role in blood-pressure regulation. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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SKU: B2012897 Categories: , Tag:


Renin Substrate 1
Catalog number: B2012897
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 2281 g/mol
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(DABCYL)-Arg
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Sparks MA, Crowley SD, Gurley SB, Mirotsou M, Coffman TM. Classical Renin-Angiotensin system in kidney physiology Compr Physiol. 2014 Jul;4(3):1201-28.
2: Rong J, Tao X, Lin Y, Zheng H, Ning L, Lu HS, Daugherty A, Shi P, Mullick AE, Chen S, Zhang Z, Xu Y, Wang J. Loss of Hepatic Angiotensinogen Attenuates Sepsis-Induced Myocardial Dysfunction Circ Res. 2021 Aug 20;129(5):547-564.
3: Ferrario CM, Groban L, Wang H, Cheng CP, VonCannon JL, Wright KN, Sun X, Ahmad S. The Angiotensin-(1-12)/Chymase axis as an alternate component of the tissue renin angiotensin system Mol Cell Endocrinol. 2021 Jun 1;529:111119.
4: Nishiyama A, Kobori H. Independent regulation of renin-angiotensin-aldosterone system in the kidney Clin Exp Nephrol. 2018 Dec;22(6):1231-1239.
5: McDonald WJ, Cohen EL, Lucas CP, Conn JW. Renin-renin substrate kinetic constants in the plasma of normal and estrogen-treated humans J Clin Endocrinol Metab. 1977 Dec;45(6):1297-304.
6: Cholewa BC, Mattson DL. Influence of elevated renin substrate on angiotensin II and arterial blood pressure in conscious mice Exp Physiol. 2005 Jul;90(4):607-12.
7: Stammers DK, Dann JG, Harris CJ, Smith DR. Comparison of angiotensinogen and tetradecapeptide as substrates for human renin. Substrate dependence of the mode of inhibition of renin by a statine-containing hexapeptide Arch Biochem Biophys. 1987 Nov 1;258(2):413-20.
8: Oelkers W, Holze C, Molzahn M, Soerensen R. Renin, renin substrate and angiotensin II concentration in renal venous blood Contrib Nephrol. 1976;3:150-9.
9: Murakami E, Hiwada K, Kokubu T. Effects of angiotension II, thyroxine and estrogen on plasma renin substrate concentration and renin substrate production by the liver Jpn Circ J. 1981 Sep;45(9):1078-82.
10: Uijl E, Ren L, Danser AHJ. Angiotensin generation in the brain: a re-evaluation Clin Sci (Lond). 2018 Apr 30;132(8):839-850.

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