Renin Fluorogenic Substrate

Description

Renin Fluorogenic Substrate
Catalog number: B2012892
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 2282.7 g/mol
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: L-arginyl-N-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]-L-glutaminyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucyl-L-valyl-L-isoleucyl-L-histidyl-L-threonyl-N6-[4-[[4-(dimethylamino)phenyl]azo]benzoyl]-L-lysyl-L-arginine
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Nakamura-Imajo N, Satomura S, Matsuura S, Murakami K. Renin assay using a fluorogenic substrate and high performance liquid chromatography Clin Chim Acta. 1992 Oct 15;211(1-2):47-57.
2: Murakami K, Ohsawa T, Hirose S, Takada K, Sakakibara S. New fluorogenic substrates for renin Anal Biochem. 1981 Jan 1;110(1):232-9.
3: Paschalidou K, Neumann U, Gerhartz B, Tzougraki C. Highly sensitive intramolecularly quenched fluorogenic substrates for renin based on the combination of L-2-amino-3-(7-methoxy-4-coumaryl)propionic acid with 2,4-dinitrophenyl groups at various positions Biochem J. 2004 Sep 15;382(Pt 3):1031-8.
4: Wang GT, Chung CC, Holzman TF, Krafft GA. A continuous fluorescence assay of renin activity Anal Biochem. 1993 May 1;210(2):351-9.
5: Zhang J, Preda DV, Vasquez KO, Morin J, Delaney J, Bao B, Percival MD, Xu D, McKay D, Klimas M, Bednar B, Sur C, Gao DZ, Madden K, Yared W, Rajopadhye M, Peterson JD. A fluorogenic near-infrared imaging agent for quantifying plasma and local tissue renin activity in vivo and ex vivo Am J Physiol Renal Physiol. 2012 Aug 15;303(4):F593-603.
6: Nakamura N, Satomura S, Matsuura S, Murakami K. Identification of the active site of human renin with use of new fluorogenic peptides J Biochem. 1991 May;109(5):741-5.
7: Peti-Peterdi J, Fintha A, Fuson AL, Tousson A, Chow RH. Real-time imaging of renin release in vitro Am J Physiol Renal Physiol. 2004 Aug;287(2):F329-35.
8: Rider SA, Christian HC, Mullins LJ, Howarth AR, MacRae CA, Mullins JJ. Zebrafish mesonephric renin cells are functionally conserved and comprise two distinct morphological populations Am J Physiol Renal Physiol. 2017 Apr 1;312(4):F778-F790.
9: Holzman TF, Chung CC, Edalji R, Egan DA, Martin M, Gubbins EJ, Krafft GA, Wang GT, Thomas AM, Rosenberg SH, et al. Characterization of recombinant human renin: kinetics, pH-stability, and peptidomimetic inhibitor binding J Protein Chem. 1991 Oct;10(5):553-63.
10: Long Y, Zhang LF, Zhang Y, Zhang CY. Single quantum dot based nanosensor for renin assay Anal Chem. 2012 Oct 16;84(20):8846-52.

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