[Pyr3]-Amyloid β-Protein (Human, 3-42)

Product Description

[Pyr3]-Amyloid β-Protein (Human, 3-42)
Catalog number: MDP0736
CAS Number: 120721-97-3
Sequence: Pyr-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
Amount: 500 ug
Molecular Weight: 4309.6 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20 °C
WARNING: For in vitro Research Use Only. NOT for use on humans or animals.
Grade: Biotechnology grade. All products are highly pure.

References:
1: Chang HH, Cheng YC, Tsai WC, Tsao MJ, Chen Y. Pyr3 Induces Apoptosis and Inhibits Migration in Human Glioblastoma Cells Cell Physiol Biochem. 2018;48(4):1694-1702.
2: Lu M, Fang XX, Shi DD, Liu R, Ding Y, Zhang QF, Wang HQ, Tang JM, He XJ. A Selective TRPC3 Inhibitor Pyr3 Attenuates Myocardial Ischemia/Reperfusion Injury in Mice Curr Med Sci. 2020 Dec;40(6):1107-1113.
3: Abdoul-Azize S, Buquet C, Vannier JP, Dubus I. Pyr3, a TRPC3 channel blocker, potentiates dexamethasone sensitivity and apoptosis in acute lymphoblastic leukemia cells by disturbing Ca(2+) signaling, mitochondrial membrane potential changes and reactive oxygen species production Eur J Pharmacol. 2016 Aug 5;784:90-8.
4: Banks GR, Taylor SY. Cloning of the PYR3 gene of Ustilago maydis and its use in DNA transformation Mol Cell Biol. 1988 Dec;8(12):5417-24.
5: Koenig S, Schernthaner M, Maechler H, Kappe CO, Glasnov TN, Hoefler G, Braune M, Wittchow E, Groschner K. A TRPC3 blocker, ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (Pyr3), prevents stent-induced arterial remodeling J Pharmacol Exp Ther. 2013 Jan;344(1):33-40.
6: Munakata M, Shirakawa H, Nagayasu K, Miyanohara J, Miyake T, Nakagawa T, Katsuki H, Kaneko S. Transient receptor potential canonical 3 inhibitor Pyr3 improves outcomes and attenuates astrogliosis after intracerebral hemorrhage in mice Stroke. 2013 Jul;44(7):1981-7.
7: Abdoul-Azize S, Dubus I, Vannier JP. [Modulation of glucocorticoid sensitivity in acute lymphoblastic leukemia: Pyr3, a new therapeutic tool?] Med Sci (Paris). 2017 Feb;33(2):130-132.
8: Spanos A, Kanuga N, Holden DW, Banks GR. The Ustilago maydis pyr3 gene: sequence and transcriptional analysis Gene. 1992 Aug 1;117(1):73-9.
9: Kiyonaka S, Kato K, Nishida M, Mori Y. [Pharmacological properties of novel TRPC channel inhibitors] Yakugaku Zasshi. 2010 Mar;130(3):303-11.
10: Sakai T, Naito AT, Kuramoto Y, Ito M, Okada K, Higo T, Nakagawa A, Shibamoto M, Yamaguchi T, Sumida T, Nomura S, Umezawa A, Miyagawa S, Sawa Y, Morita H, Lee JK, Shiojima I, Sakata Y, Komuro I. Phenotypic Screening Using Patient-Derived Induced Pluripotent Stem Cells Identified Pyr3 as a Candidate Compound for the Treatment of Infantile Hypertrophic Cardiomyopathy Int Heart J. 2018 Sep 26;59(5):1096-1105.

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