Puma BH3 Domain Peptide


Catalog Number: B2012684 (500 ug)
Puma BH3 Domain Peptide is a high quality synthetic puma BH3 domain peptide. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

Live enquiry about this product via Text/SMS: 1-858-900-3210.

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SKU: B2012684 Categories: , Tag:


Puma BH3 Domain Peptide
Catalog number: B2012684
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 500 ug
Molecular Weight or Concentration: N/A
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: 2-8°C
Keywords: Bcl-2-binding component 3, p53 up-regulated modulator of apoptosis, Bbc3, Puma
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M. Impaired autophagy and APP processing in Alzheimer’s disease: The potential role of Beclin 1 interactome Prog Neurobiol. 2013 Jul-Aug;106-107:33-54.
2: Han CW, Lee HN, Jeong MS, Park SY, Jang SB. Structural basis of the p53 DNA binding domain and PUMA complex Biochem Biophys Res Commun. 2021 Apr 9;548:39-46.
3: Wu X, Deng Y. Bax and BH3-domain-only proteins in p53-mediated apoptosis Front Biosci. 2002 Jan 1;7:d151-6.
4: Delgado-Soler L, Pinto M, Tanaka-Gil K, Rubio-Martinez J. Molecular determinants of Bim(BH3) peptide binding to pro-survival proteins J Chem Inf Model. 2012 Aug 27;52(8):2107-18.
5: Day CL, Smits C, Fan FC, Lee EF, Fairlie WD, Hinds MG. Structure of the BH3 domains from the p53-inducible BH3-only proteins Noxa and Puma in complex with Mcl-1 J Mol Biol. 2008 Jul 25;380(5):958-71.
6: Lee EF, Smith BJ, Horne WS, Mayer KN, Evangelista M, Colman PM, Gellman SH, Fairlie WD. Structural basis of Bcl-xL recognition by a BH3-mimetic α/β-peptide generated by sequence-based design Chembiochem. 2011 Sep 5;12(13):2025-32.
7: Holzerland J, Fénéant L, Banadyga L, Hölper JE, Knittler MR, Groseth A. BH3-only sensors Bad, Noxa and Puma are Key Regulators of Tacaribe virus-induced Apoptosis PLoS Pathog. 2020 Oct 12;16(10):e1008948.
8: Stadler LK, Tomlinson DC, Lee T, Knowles MA, Ko Ferrigno P. The use of a neutral peptide aptamer scaffold to anchor BH3 peptides constitutes a viable approach to studying their function Cell Death Dis. 2014 Jan 30;5(1):e1037.
9: Liu Y, Li Y, Wang H, Yu J, Lin H, Xu D, Wang Y, Liang A, Liang X, Zhang X, Fu M, Qian H, Lin C. BH3-based fusion artificial peptide induces apoptosis and targets human colon cancer Mol Ther. 2009 Sep;17(9):1509-16.
10: Plötz M, Hossini AM, Gillissen B, Daniel PT, Stockfleth E, Eberle J. Mutual regulation of Bcl-2 proteins independent of the BH3 domain as shown by the BH3-lacking protein Bcl-x(AK) PLoS One. 2012;7(4):e34549.

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