PKCe Peptide Substrate


Catalog Number: B2011346 (1 mg)
PKCe Peptide Substrate is a high quality peptide (ERMRPRKRQGSVRRRV) which corresponds to pseudosubstrate region of the e-isotype of protein kinase C (PKCe) with an alanine to serine substitution. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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SKU: B2011346 Categories: ,


PKCe Peptide Substrate
Catalog number: B2011346
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 2067.5 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: PKCepsilon Peptide Substrate, Protein Kinase C
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Schwendt M, Olive MF. Protein kinase Cɛ activity regulates mGluR5 surface expression in the rat nucleus accumbens J Neurosci Res. 2017 Apr;95(4):1079-1090.
2: Dann SG, Golas J, Miranda M, Shi C, Wu J, Jin G, Rosfjord E, Upeslacis E, Klippel A. p120 catenin is a key effector of a Ras-PKCɛ oncogenic signaling axis Oncogene. 2014 Mar 13;33(11):1385-94.
3: Hamilton D, Rugg C, Davis N, Kvezereli M, Tafti BA, Busque S, Fontaine M. A preconditioning regimen with a PKCɛ activator improves islet graft function in a mouse transplant model Cell Transplant. 2014;23(7):913-9.
4: Sen A, Nelson TJ, Alkon DL, Hongpaisan J. Loss in PKC Epsilon Causes Downregulation of MnSOD and BDNF Expression in Neurons of Alzheimer’s Disease Hippocampus J Alzheimers Dis. 2018;63(3):1173-1189.
5: Foerster F, Braig S, Moser C, Kubisch R, Busse J, Wagner E, Schmoeckel E, Mayr D, Schmitt S, Huettel S, Zischka H, Mueller R, Vollmar AM. Targeting the actin cytoskeleton: selective antitumor action via trapping PKCɛ Cell Death Dis. 2014 Aug 28;5(8):e1398.
6: Li L, Zhao L, Wang Y, Ma KT, Shi WY, Wang YZ, Si JQ. PKCɛ mediates substance P inhibition of GABAA receptors-mediated current in rat dorsal root ganglion J Huazhong Univ Sci Technolog Med Sci. 2015 Feb;35(1):1-9.
7: Nelson TJ, Sun MK, Lim C, Sen A, Khan T, Chirila FV, Alkon DL. Bryostatin Effects on Cognitive Function and PKCɛ in Alzheimer’s Disease Phase IIa and Expanded Access Trials J Alzheimers Dis. 2017;58(2):521-535.
8: Loi TH, Dai P, Carlin S, Melo JV, Ma DDF. Pro-survival role of protein kinase C epsilon in Philadelphia chromosome positive acute leukemia Leuk Lymphoma. 2016 Feb;57(2):411-418.
9: Brandon AE, Liao BM, Diakanastasis B, Parker BL, Raddatz K, McManus SA, O’Reilly L, Kimber E, van der Kraan AG, Hancock D, Henstridge DC, Meikle PJ, Cooney GJ, James DE, Reibe S, Febbraio MA, Biden TJ, Schmitz-Peiffer C. Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance Cell Metab. 2019 Jan 8;29(1):183-191.e7.
10: Cohan CH, Stradecki-Cohan HM, Morris-Blanco KC, Khoury N, Koronowski KB, Youbi M, Wright CB, Perez-Pinzon MA. Protein kinase C epsilon delays latency until anoxic depolarization through arc expression and GluR2 internalization J Cereb Blood Flow Metab. 2017 Dec;37(12):3774-3788.

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