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Oncostatin-M (Human Recombinant)

$695.00 $495.00

Catalog Number: B2010320 (10 ug)
Oncostatin-M (Human Recombinant) is a high quality research product used as highly pure Oncostatin-M (Human Recombinant) expressed in E. coli. This protein acts as a polypeptide chain containing 227 amino acids that acts as a cytokine belonging to the IL-6 family and has multiple functions in hematopoiesis and other functions. Custom bulk orders of this product are available upon request.

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SKU: B2010320 Categories: , ,

Description

Oncostatin-M (Human Recombinant)
Catalog number: B2010320
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Oncostatin-M (Human Recombinant) expressed in E. coli. This protein acts as a polypeptide chain containing 227 amino acids that acts as a cytokine belonging to the IL-6 family and has multiple functions in hematopoiesis and other functions.
Storage: -20C
Keywords: rHuOSM; OSM
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Hermanns HM. Oncostatin M and interleukin-31: Cytokines, receptors, signal
transduction and physiology. Cytokine Growth Factor Rev. 2015 Oct;26(5):545-58.

2: West NR, Hegazy AN, Owens BMJ, Bullers SJ, Linggi B, Buonocore S, Coccia M,
Görtz D, This S, Stockenhuber K, Pott J, Friedrich M, Ryzhakov G, Baribaud F,
Brodmerkel C, Cieluch C, Rahman N, Müller-Newen G, Owens RJ, Kühl AA, Maloy KJ,
Plevy SE; Oxford IBD Cohort Investigators, Keshav S, Travis SPL, Powrie F.
Oncostatin M drives intestinal inflammation and predicts response to tumor
necrosis factor-neutralizing therapy in patients with inflammatory bowel
disease. Nat Med. 2017 May;23(5):579-589.

3: Verstockt S, Verstockt B, Vermeire S. Oncostatin M as a new diagnostic,
prognostic and therapeutic target in inflammatory bowel disease (IBD). Expert
Opin Ther Targets. 2019 Nov;23(11):943-954.

4: Abe H, Takeda N, Isagawa T, Semba H, Nishimura S, Morioka MS, Nakagama Y,
Sato T, Soma K, Koyama K, Wake M, Katoh M, Asagiri M, Neugent ML, Kim JW,
Stockmann C, Yonezawa T, Inuzuka R, Hirota Y, Maemura K, Yamashita T, Otsu K,
Manabe I, Nagai R, Komuro I. Macrophage hypoxia signaling regulates cardiac
fibrosis via Oncostatin M. Nat Commun. 2019 Jun 27;10(1):2824.

5: Houben E, Hellings N, Broux B. Oncostatin M, an Underestimated Player in the
Central Nervous System. Front Immunol. 2019 May 29;10:1165.

6: Houben E, Janssens K, Hermans D, Vandooren J, Van den Haute C, Schepers M,
Vanmierlo T, Lambrichts I, van Horssen J, Baekelandt V, Opdenakker G, Baron W,
Broux B, Slaets H, Hellings N. Oncostatin M-induced astrocytic tissue inhibitor
of metalloproteinases-1 drives remyelination. Proc Natl Acad Sci U S A. 2020 Mar
3;117(9):5028-5038.

7: Matsuda M, Tsurusaki S, Miyata N, Saijou E, Okochi H, Miyajima A, Tanaka M.
Oncostatin M causes liver fibrosis by regulating cooperation between hepatic
stellate cells and macrophages in mice. Hepatology. 2018 Jan;67(1):296-312.

8: West NR, Owens BMJ, Hegazy AN. The oncostatin M-stromal cell axis in health
and disease. Scand J Immunol. 2018 Sep;88(3):e12694.

9: Stephens JM, Elks CM. Oncostatin M: Potential Implications for Malignancy and
Metabolism. Curr Pharm Des. 2017;23(25):3645-3657.

10: Wang ECE, Dai Z, Ferrante AW, Drake CG, Christiano AM. A Subset of
TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair
Follicle Stem Cell Quiescence and Inhibit Hair Growth. Cell Stem Cell. 2019 Apr
4;24(4):654-669.e6.
11: Foglia B, Sutti S, Pedicini D, Cannito S, Bocca C, Maggiora M, Bevacqua MR,
Rosso C, Bugianesi E, Albano E, Novo E, Parola M. Oncostatin M, A Profibrogenic
Mediator Overexpressed in Non-Alcoholic Fatty Liver Disease, Stimulates
Migration of Hepatic Myofibroblasts. Cells. 2019 Dec 20;9(1):28.

Products Related to Oncostatin-M (Human Recombinant) : Proteins

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