Neuromedin U (Human)

Product Description

Neuromedin U (Human)
Catalog number: MDP0841
Name: Phe-Arg-Val-Asp-Glu-Glu-Phe-Gln-Ser-Pro-Phe-Ala-Ser-Gln-Ser-Arg-Gly-Tyr-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2
Other name(s): Neuromedin U (Human), Neuromedin U-25 (Human)
Molecular Formula: C₁₄₁H₂₀₃N₄₁O₃₈
Molar Mass: 3080.4
Form: Aqueous solution
Storage Temperature: -20°C

WARNING:
This product if for Research Use Only (RUO). This product is not for administration to humans or animals. This product is not for human or veterinary diagnostic or therapeutic use.

References:
1: Ye Y, Luo J, Zeng N, Jiang S, Chen W, Hoyle RD, Klenerman P, Pavord ID, Xue L. Neuromedin U promotes human type 2 immune responses Mucosal Immunol. 2022 May;15(5):990-999.
2: De Prins A, Van Eeckhaut A, Smolders I, Tourwé D, Ballet S. Neuromedin U and Structural Analogs: An Overview of their Structure, Function and Selectivity Curr Med Chem. 2020;27(39):6744-6768.
3: Tsou AM, Yano H, Parkhurst CN, Mahlakõiv T, Chu C, Zhang W, He Z, Jarick KJ, Zhong C, Putzel GG, Hatazaki M; JRI IBD Live Cell Bank Consortium; Lorenz IC, Andrew D, Balderes P, Klose CSN, Lira SA, Artis D. Neuropeptide regulation of non-redundant ILC2 responses at barrier surfaces Nature. 2022 Nov;611(7937):787-793.
4: Grippi C, Izzi B, Gianfagna F, Noro F, Falcinelli E, Di Pardo A, Amico E, Donati MB, de Gaetano G, Iacoviello L, Hoylaerts MF, Cerletti C. Neuromedin U potentiates ADP- and epinephrine-induced human platelet activation Thromb Res. 2017 Nov;159:100-108.
5: Ye Y, Liang Z, Xue L. Neuromedin U: potential roles in immunity and inflammation Immunology. 2021 Jan;162(1):17-29.
6: You C, Zhang Y, Xu P, Huang S, Yin W, Eric Xu H, Jiang Y. Structural insights into the peptide selectivity and activation of human neuromedin U receptors Nat Commun. 2022 Apr 19;13(1):2045.
7: Teranishi H, Hanada R. Neuromedin U, a Key Molecule in Metabolic Disorders Int J Mol Sci. 2021 Apr 19;22(8):4238.
8: Nagashima H, Mahlakõiv T, Shih HY, Davis FP, Meylan F, Huang Y, Harrison OJ, Yao C, Mikami Y, Urban JF Jr, Caron KM, Belkaid Y, Kanno Y, Artis D, O’Shea JJ. Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation Immunity. 2019 Oct 15;51(4):682-695.e6.
9: Kuhre RE, Christiansen CB, Ghiasi SM, Gabe MBN, Skat-Rørdam PA, Modvig IM, Mandrup-Poulsen T, Albrechtsen R, Rosenkilde MM, Hartmann B, Wewer Albrechtsen NJ, Holst JJ. Neuromedin U Does Not Act as a Decretin in Rats Cell Metab. 2019 Mar 5;29(3):719-726.e5.
10: Martinez VG, O’Driscoll L. Neuromedin U: a multifunctional neuropeptide with pleiotropic roles Clin Chem. 2015 Mar;61(3):471-82.

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