MCLA Chemiluminescence Substrate

Product Description

MCLA Chemiluminescence Substrate
Catalog number: B2012187
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 mg
Molecular Weight or Concentration: 291.74 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: 2-Methyl-6-(4-methoxyphenyl)-3,7-dihydroimidazo[1,2-a]pyrazin-3-one Hydrochloride, 6-(4-Methoxyphenyl)-2-methyl-3,7-dihydroimidazo[1,2-a]pyrazin-3-one Hydrochloride
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Kambayashi Y, Ogino K. Reestimation of Cypridina luciferin analogs (MCLA) as a chemiluminescence probe to detect active oxygen species–cautionary note for use of MCLA J Toxicol Sci. 2003 Aug;28(3):139-48.
2: Arisawa F, Tatsuzawa H, Kambayashi Y, Kuwano H, Fujimori K, Nakano M. MCLA-dependent chemiluminescence suggests that singlet oxygen plays a pivotal role in myeloperoxidase-catalysed bactericidal action in neutrophil phagosomes Luminescence. 2003 Jul-Aug;18(4):229-38.
3: Tampo Y, Tsukamoto M, Yonaha M. The antioxidant action of 2-methyl-6-(p-methoxyphenyl)-3,7-dihydroimidazo[1,2-alpha]pyra z in-3-one (MCLA), a chemiluminescence probe to detect superoxide anions FEBS Lett. 1998 Jul 3;430(3):348-52.
4: Wang J, Xing D. Detection of vitamin C-induced singlet oxygen formation in oxidized LDL using MCLA as a chemiluminescence probe Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2002 Jan;34(1):11-5.
5: Prónai L, Nakazawa H, Ichimori K, Saigusa Y, Ohkubo T, Hiramatsu K, Arimori S, Fehér J. Time course of superoxide generation by leukocytes–the MCLA chemiluminescence system Inflammation. 1992 Oct;16(5):437-50.
6: Wang J, Xu M, Chen M, Jiang Z, Chen G. Study on sonodynamic activity of metallophthalocyanine sonosensitizers based on the sonochemiluminescence of MCLA Ultrason Sonochem. 2012 Mar;19(2):237-42.
7: Hosaka S, Obuki M, Nakajima J, Suzuki M. Comparative study of antioxidants as quenchers or scavengers of reactive oxygen species based on quenching of MCLA-dependent chemiluminescence Luminescence. 2005 Nov-Dec;20(6):419-27.
8: Teranishi K. Non-invasive and accurate readout of superoxide anion in biological systems by near-infrared light Anal Chim Acta. 2021 Sep 22;1179:338827.
9: Takeshita K, Okazaki S, Itoda A. Nitroxyl radicals remarkably enhanced the superoxide anion radical-induced chemiluminescence of Cypridina luciferin analogues Anal Chem. 2013 Jul 16;85(14):6833-9.
10: Oosthuizen MM, Engelbrecht ME, Lambrechts H, Greyling D, Levy RD. The effect of pH on chemiluminescence of different probes exposed to superoxide and singlet oxygen generators J Biolumin Chemilumin. 1997 Nov-Dec;12(6):277-84.

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