Luotonin E

Description

Luotonin E
Catalog number: B2013645
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 mg
Molecular Weight or Concentration: 315.3 g/mol
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: Luotonin E
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Hao Y, Wang K, Wang Z, Liu Y, Ma D, Wang Q. Luotonin A and Its Derivatives as Novel Antiviral and Antiphytopathogenic Fungus Agents J Agric Food Chem. 2020 Aug 19;68(33):8764-8773.
2: Wu F, Dong W, Fan S, Yuan Y, Liang C, Chen A, Yin Z, Zhang Z. Rapid Synthesis of Luotonin A Derivatives via Synergistic Visible-Light Photoredox and Acid Catalysis J Org Chem. 2022 Jan 21;87(2):1302-1312.
3: Kwon SH, Seo HA, Cheon CH. Total Synthesis of Luotonin A and Rutaecarpine from an Aldimine via the Designed Cyclization Org Lett. 2016 Oct 21;18(20):5280-5283.
4: Jahng Y, Kwon OK, Lee S. In vitro inhibitory effect of luotonin A on human CYP1A Arch Pharm Res. 2012 Dec;35(12):2199-203.
5: Cagir A, Jones SH, Gao R, Eisenhauer BM, Hecht SM. Luotonin A. A naturally occurring human DNA topoisomerase I poison J Am Chem Soc. 2003 Nov 12;125(45):13628-9.
6: Lee S, Lee J, Jahng Y, Jeong TC, Kim DH. Characterization of in vitro metabolites of luotonin A in human liver microsomes using electrospray/tandem mass spectrometry Xenobiotica. 2013 Jun;43(6):527-33.
7: Yang GZ, Zhang J, Peng JW, Zhang ZJ, Zhao WB, Wang RX, Ma KY, Li JC, Liu YQ, Zhao ZM, Shang XF. Discovery of luotonin A analogues as potent fungicides and insecticides: Design, synthesis and biological evaluation inspired by natural alkaloid Eur J Med Chem. 2020 May 15;194:112253.
8: Ibric A, Dutter K, Marian B, Haider N. A Facile Oxidative Opening of the C-Ring in Luotonin A and Derivatives Molecules. 2017 Sep 12;22(9):1540.
9: Ibric A, Battisti V, Deckardt S, Haller AV, Lee C, Partech C, Langer T, Heffeter P, Schueffl HH, Marian B, Haider N. A-ring and E-ring modifications of the cytotoxic alkaloid Luotonin A: Synthesis, computational and biological studies Bioorg Med Chem. 2020 May 1;28(9):115443.
10: Gonzalez-Ruiz V, Pascua I, Fernandez-Marcelo T, Ribelles P, Bianchini G, Sridharan V, Iniesta P, Ramos MT, Olives AI, Marta MA, Menendez JC. B-ring-aryl substituted luotonin A analogues with a new binding mode to the topoisomerase 1-DNA complex show enhanced cytotoxic activity PLoS One. 2014 May 15;9(5):e95998.

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