Keyhole Limpet Hemocyanin (KLH)

Product Description

Keyhole Limpet Hemocyanin (KLH)
Catalog number: B2010482
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 mg
Molecular Weight or Concentration: 4 MDa
Supplied as: Lyophilized Powder (also available as Liquid Solution)
Applications: a strong immune-stimulant
Storage: 2-8°C
Keywords: KLH, Hemocyanin from Megathura crenulata
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Harris JR, Markl J. Keyhole limpet hemocyanin (KLH): a biomedical review.
Micron. 1999 Dec;30(6):597-623.

2: Lamm DL, DeHaven JI, Riggs DR, Ebert RF. Immunotherapy of murine bladder
cancer with keyhole limpet hemocyanin (KLH). J Urol. 1993 Mar;149(3):648-52.

3: Giesecke C, Meyer T, Durek P, Maul J, Preiß J, Jacobs JFM, Thiel A, Radbruch
A, Ullrich R, Dörner T. Simultaneous Presence of Non- and Highly Mutated Keyhole
Limpet Hemocyanin (KLH)-Specific Plasmablasts Early after Primary KLH
Immunization Suggests Cross-Reactive Memory B Cell Activation. J Immunol. 2018
Jun 15;200(12):3981-3992.

4: Wimmers F, de Haas N, Scholzen A, Schreibelt G, Simonetti E, Eleveld MJ,
Brouwers HM, Beldhuis-Valkis M, Joosten I, de Jonge MI, Gerritsen WR, de Vries
IJ, Diavatopoulos DA, Jacobs JF. Monitoring of dynamic changes in Keyhole Limpet
Hemocyanin (KLH)-specific B cells in KLH-vaccinated cancer patients. Sci Rep.
2017 Mar 7;7:43486.

5: Chang P, Huang L, Huang M, Tian S, Yang Z. Improvement and optimization of a
T-cell-dependent antibody response (TDAR) method for BALB/c mice using keyhole
limpet_hemocyanin (KLH) as specific antigen. J Immunotoxicol. 2019
Dec;16(1):149-154. PMID: 31290717.

6: Beach GA, Habib MR, El Hiani Y, Miller MW, Croll RP. Localization of keyhole
limpet_hemocyanin-like immunoreactivity in the nervous system of Biomphalaria
alexandrina. J Neurosci Res. 2019 Nov;97(11):1469-1482.

7: Yasuda K, Ushio H. Keyhole_limpet hemocyanin induces innate immunity via Syk
and Erk phosphorylation. EXCLI J. 2016 Aug 3;15:474-481.

8: Schumacher K. Keyhole_limpet_hemocyanin (KLH) conjugate vaccines as novel
therapeutic tools in malignant disorders. J Cancer Res Clin Oncol. 2001 Oct;127
Suppl 2:R1-2.

9: Adluri S, Helling F, Ogata S, Zhang S, Itzkowitz SH, Lloyd KO, Livingston PO.
Immunogenicity of synthetic TF-KLH (keyhole limpet hemocyanin) and sTn-KLH
conjugates in colorectal carcinoma patients. Cancer Immunol Immunother. 1995
Sep;41(3):185-92.
10: Harris JR, Markl J. Keyhole limpet hemocyanin: molecular structure of a
potent marine immunoactivator. A review. Eur Urol. 2000;37 Suppl 3:24-33.

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