JC-1 (Highly Pure)

Product Description

JC-1 (Highly Pure)
Catalog number: B2011451
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 2.5 mg
Molecular Weight or Concentration: 652.2 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodide
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Perelman A, Wachtel C, Cohen M, Haupt S, Shapiro H, Tzur A. JC-1: alternative excitation wavelengths facilitate mitochondrial membrane potential cytometry Cell Death Dis. 2012 Nov 22;3(11):e430.
2: Marcondes NA, Terra SR, Lasta CS, Hlavac NRC, Dalmolin ML, Lacerda LA, Faulhaber GAM, González FHD. Comparison of JC-1 and MitoTracker probes for mitochondrial viability assessment in stored canine platelet concentrates: A flow cytometry study Cytometry A. 2019 Feb;95(2):214-218.
3: Elefantova K, Lakatos B, Kubickova J, Sulova Z, Breier A. Detection of the Mitochondrial Membrane Potential by the Cationic Dye JC-1 in L1210 Cells with Massive Overexpression of the Plasma Membrane ABCB1 Drug Transporter Int J Mol Sci. 2018 Jul 7;19(7):1985.
4: Hsieh CC, Li CY, Hsu CH, Chen HL, Chen YH, Liu YP, Liu YR, Kuo HF, Liu PL. Mitochondrial protection by simvastatin against angiotensin II-mediated heart failure Br J Pharmacol. 2019 Oct;176(19):3791-3804.
5: Nowicka-Bauer K, Lepczynski A, Ozgo M, Kamieniczna M, Fraczek M, Stanski L, Olszewska M, Malcher A, Skrzypczak W, Kurpisz MK. Sperm mitochondrial dysfunction and oxidative stress as possible reasons for isolated asthenozoospermia J Physiol Pharmacol. 2018 Jun;69(3).
6: Małota K, Student S, Świątek P. Low mitochondrial activity within developing earthworm male germ-line cysts revealed by JC-1 Mitochondrion. 2019 Jan;44:111-121.
7: Al-Zubaidi U, Liu J, Cinar O, Robker RL, Adhikari D, Carroll J. The spatio-temporal dynamics of mitochondrial membrane potential during oocyte maturation Mol Hum Reprod. 2019 Nov 30;25(11):695-705.
8: Suski JM, Lebiedzinska M, Bonora M, Pinton P, Duszynski J, Wieckowski MR. Relation between mitochondrial membrane potential and ROS formation Methods Mol Biol. 2012;810:183-205.
9: Sun L, Wang H, Yu S, Zhang L, Jiang J, Zhou Q. Herceptin induces ferroptosis and mitochondrial dysfunction in H9c2 cells Int J Mol Med. 2022 Feb;49(2):17.
10: Chuang KC, Chang CR, Chang SH, Huang SW, Chuang SM, Li ZY, Wang ST, Kao JK, Chen YJ, Shieh JJ. Imiquimod-induced ROS production disrupts the balance of mitochondrial dynamics and increases mitophagy in skin cancer cells J Dermatol Sci. 2020 Jun;98(3):152-162.

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