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Calpain Fluorogenic Substrate

Original price was: $995.00.Current price is: $495.00.

Catalog Number: B2011074 (5 mg)
Calpain Fluorogenic Substrate is a highly pure 7-amino-4-methylcoumarin (AMC)-labelled peptide (Suc-LLVY-AMC) for Calpain. This product has been used as molecular tool for various chemical, biochemical and immunological applications. It has also been used in a wide array of other biochemical and immunological applications. Custom bulk amounts of this product are available upon request.

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Product Description

4.9/5 - (7 votes)

Calpain Fluorogenic Substrate
Catalog number: B2011074
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 mg
Molecular Weight or Concentration: 763.9 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various chemical, biochemical and immunological applications
Storage: -20 °C
Keywords: Suc-LLVY-AMC
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Campbell JS, Hallett MB. Active calpain in phagocytically competent human neutrophils: electroinjection of fluorogenic calpain substrate Biochem Biophys Res Commun. 2015 Feb 13;457(3):341-6.
2: Cardoso M, Oliveira D, Araujo H. Expression and Activity of Calpain A in Drosophila melanogaster Methods Mol Biol. 2019;1915:93-101.
3: Tompa P, Buzder-Lantos P, Tantos A, Farkas A, Szilágyi A, Bánóczi Z, Hudecz F, Friedrich P. On the sequential determinants of calpain cleavage J Biol Chem. 2004 May 14;279(20):20775-85.
4: Mallya SK, Meyer S, Bozyczko-Coyne D, Siman R, Ator MA. A sensitive, continuously recording fluorogenic assay for calpain Biochem Biophys Res Commun. 1998 Jul 20;248(2):293-6.
5: Koller G, Schürholz E, Ziebart T, Neff A, Frankenberger R, Bartsch JW. Clinical Evaluation of Pathognomonic Salivary Protease Fingerprinting for Oral Disease Diagnosis J Pers Med. 2021 Aug 30;11(9):866.
6: Jennings S, Hallett MB. Single cell measurement of calpain activity in neutrophils reveals link to cytosolic Ca(2+) elevation and individual phagocytotic events Biochem Biophys Res Commun. 2019 Jul 12;515(1):163-168.
7: Kitagawa Y, Tanaka S, Kamiya M, Kuriki Y, Yamamoto K, Shimizu T, Nejo T, Hana T, Matsuura R, Koike T, Yamazawa E, Kushihara Y, Takahashi S, Nomura M, Takami H, Takayanagi S, Mukasa A, Urano Y, Saito N. A Novel Topical Fluorescent Probe for Detection of Glioblastoma Clin Cancer Res. 2021 Jul 15;27(14):3936-3947.
8: Ali MA, Stepanko A, Fan X, Holt A, Schulz R. Calpain inhibitors exhibit matrix metalloproteinase-2 inhibitory activity Biochem Biophys Res Commun. 2012 Jun 22;423(1):1-5.
9: Sasaki T, Kikuchi T, Yumoto N, Yoshimura N, Murachi T. Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates J Biol Chem. 1984 Oct 25;259(20):12489-94.
10: Mendoza PA, Silva P, Díaz J, Arriagada C, Canales J, Cerda O, Torres VA. Calpain2 mediates Rab5-driven focal adhesion disassembly and cell migration Cell Adh Migr. 2018 May 4;12(3):185-194.

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Additional Information

Weight 0.15 oz
Dimensions 2 × 0.5 × 0.5 in
4.9/5 - (7 votes)

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