IRAK-4 Peptide Substrate


Catalog Number: B2011450 (1 mg)
IRAK-4 Peptide Substrate is a high quality substrate peptide for Interleukin-1 Receptor-Associated Kinase (IRAK) 4. This product has been used as molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request.

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SKU: B2011450 Categories: ,


IRAK-4 Peptide Substrate
Catalog number: B2011450
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 mg
Molecular Weight or Concentration: 2285.7 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: -20 °C
Keywords: IRAK-4 Peptide Substrate; IRAK-1 (360-380)
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

1: Wang Z, Liu J, Sudom A, Ayres M, Li S, Wesche H, Powers JP, Walker NP. Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper Structure. 2006 Dec;14(12):1835-44.
2: Hekmat-Nejad M, Cai T, Swinney DC. Steady-state kinetic characterization of kinase activity and requirements for Mg2+ of interleukin-1 receptor-associated kinase-4 Biochemistry. 2010 Feb 23;49(7):1495-506.
3: Böl GF, Jurrmann N, Brigelius-Flohé R. Cellular trafficking of the IL-1RI-associated kinase-1 requires intact kinase activity Biochem Biophys Res Commun. 2005 Jun 24;332(1):279-87.
4: Dunne A, Carpenter S, Brikos C, Gray P, Strelow A, Wesche H, Morrice N, O’Neill LA. IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal) J Biol Chem. 2010 Jun 11;285(24):18276-82.
5: Vollmer S, Strickson S, Zhang T, Gray N, Lee KL, Rao VR, Cohen P. The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists Biochem J. 2017 Jun 6;474(12):2027-2038.
6: Zhang G, Ghosh S. Negative regulation of toll-like receptor-mediated signaling by Tollip J Biol Chem. 2002 Mar 1;277(9):7059-65.
7: Kim JA, Yeh DC, Ver M, Li Y, Carranza A, Conrads TP, Veenstra TD, Harrington MA, Quon MJ. Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute to insulin resistance J Biol Chem. 2005 Jun 17;280(24):23173-83.
8: Hazeki K, Masuda N, Funami K, Sukenobu N, Matsumoto M, Akira S, Takeda K, Seya T, Hazeki O. Toll-like receptor-mediated tyrosine phosphorylation of paxillin via MyD88-dependent and -independent pathways Eur J Immunol. 2003 Mar;33(3):740-7.
9: Wan YS, Wang ZQ, Voorhees J, Fisher G. EGF receptor crosstalks with cytokine receptors leading to the activation of c-Jun kinase in response to UV irradiation in human keratinocytes Cell Signal. 2001 Feb;13(2):139-44.
10: Böl GF, Tewes F, Brigelius-Flohé R. Interleukin-1 signaling is dependent on free thiols Biofactors. 1999;10(2-3):175-8.

Products Related to IRAK-4 Peptide Substrate can be found at Substrates

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