Interferon-lambda1 (Interleukin-29)

Description

Interferon-lambda1 (Interleukin-29)
Catalog number: B2010307
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: 7.4 upon reconstitution
Supplied as: Lyophilized Powder
Appearance: Powder
Applications: highly pure Interferon-lambda1 (Interleukin-29) expressed in E. coli. This protein acts as a member of the interferon lambda family, with immunoregulatory, antiviral, anti-proliferative, and antitumor properties.
Storage: -20C
Keywords: rHuIFN-λ1/IL-29; IL-29; IFN-lambda-1; Cytokine Zcyto21; Interleukin-29
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Liu S, Fang P, Ke W, Wang J, Wang X, Xiao S, Fang L. Porcine deltacoronavirus
(PDCoV) infection antagonizes interferon-λ1 production. Vet Microbiol. 2020
Aug;247:108785.

2: Chen Y, Wang Y, Tang R, Yang J, Dou C, Dong Y, Sun D, Zhang C, Zhang L, Tang
Y, Dai Q, Luo F, Xu J, Dong S. Dendritic cells-derived interferon-λ1 ameliorated
inflammatory bone destruction through inhibiting osteoclastogenesis. Cell Death
Dis. 2020 Jun 2;11(6):414.

3: Yuan WM, Zhang R, Zhang Q, Ma FL, Wang C, Wang YZ, Zeng Y, Zheng LS. The
generation and biological activity of a long-lasting recombinant human
interferon-λ1. Protein Eng Des Sel. 2018 Sep 1;31(9):355-360.

4: Gao D, Zhao J, Li X, Xia Y, Cai Y, Pan J, Zhou H, Fang Y, Zhang S, Wen H.
Interferon-λ1 suppresses invasion and enhances autophagy in human osteosarcoma
cell. Int J Clin Exp Med. 2015 Sep 15;8(9):14999-5004.

5: Chrysanthopoulou A, Kambas K, Stakos D, Mitroulis I, Mitsios A, Vidali V,
Angelidou I, Bochenek M, Arelaki S, Arampatzioglou A, Galani IE, Skendros P,
Couladouros EA, Konstantinides S, Andreakos E, Schäfer K, Ritis K. Interferon
lambda1/IL-29 and inorganic polyphosphate are novel regulators of neutrophil-
driven thromboinflammation. J Pathol. 2017 Sep;243(1):111-122.

6: Zhang L, Li W, Sun Y, Li X, Kong L, Xu P, Xia P, Yue J. Activation of
activating Fc gamma receptors down-regulates the levels of interferon β,
interferon γ and interferon λ1 in porcine alveolar macrophages during PRRSV
infection. Int Immunopharmacol. 2020 Apr;81:106268.

7: Hsu YL, Wang MY, Ho LJ, Lai JH. Dengue virus infection induces interferon-
lambda1 to facilitate cell migration. Sci Rep. 2016 Jul 26;6:24530.

8: Gielen V, Johnston SL, Edwards MR. Azithromycin induces anti-viral responses
in bronchial epithelial cells. Eur Respir J. 2010 Sep;36(3):646-54.

9: Liu D, Chang CH, Rossi EA, Cardillo TM, Goldenberg DM. Interferon-λ1 linked
to a stabilized dimer of Fab potently enhances both antitumor and antiviral
activities in targeted cells. PLoS One. 2013 May 16;8(5):e63940.

10: Chang CY, Liu HM, Chang MF, Chang SC. Middle East Respiratory Syndrome
Coronavirus Nucleocapsid Protein Suppresses Type I and Type III Interferon
Induction by Targeting RIG-I Signaling. J Virol. 2020 Jun 16;94(13):e00099-20.

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