Hydroxocobalamin Acetate (Highly Pure)

Product Description

Hydroxocobalamin Acetate (Highly Pure)
Catalog number: B2011252
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 1 g
Molecular Weight or Concentration: 1388.4 g/mol
Supplied as: Lyophilized
Applications: molecular tool for various biochemical applications
Storage: 2-8 °C
Keywords: Vitamin B12 Physiological Equivalent, HC
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Thompson A, Dunn M, Jefferson RD, Dissanayake K, Reed F, Gregson R, Greenhalgh S, Clutton RE, Blain PG, Thomas SH, Eddleston M. Modest and variable efficacy of pre-exposure hydroxocobalamin and dicobalt edetate in a porcine model of acute cyanide salt poisoning Clin Toxicol (Phila). 2020 Mar;58(3):190-200.
2: MacLennan L, Moiemen N. Management of cyanide toxicity in patients with burns Burns. 2015 Feb;41(1):18-24.
3: EVANS CL. COBALT COMPOUNDS AS ANTIDOTES FOR HYDROCYANIC ACID Br J Pharmacol Chemother. 1964 Dec;23(3):455-75.
4: Elliott TR, Guildford AL. An In Vitro Model of Gastric Inflammation and Treatment with Cobalamin Int J Inflam. 2017;2017:5968618.
5: Cao N, Wong YG, Rosli S, Kiriazis H, Huynh K, Qin C, Du XJ, Kemp-Harper BK, Ritchie RH. Chronic administration of the nitroxyl donor 1-nitrosocyclo hexyl acetate limits left ventricular diastolic dysfunction in a mouse model of diabetes mellitus in vivo Circ Heart Fail. 2015 May;8(3):572-81.
6: MARCUS AD, STANLEY JL. STABILITY OF THE COBALAMIN MOIETY IN BUFFERED AQUEOUS SOLUTIONS OF HYDROXOCOBALAMIN J Pharm Sci. 1964 Jan;53:91-4.
7: Ramsay ID, Rushton DH. Reduced serum vitamin B12 levels during oral cyproterone-acetate and ethinyl-oestradiol therapy in women with diffuse androgen-dependent alopecia Clin Exp Dermatol. 1990 Jul;15(4):277-81.
8: Hashsham SA, Freedman DL. Enhanced biotransformation of carbon tetrachloride by Acetobacterium woodii upon addition of hydroxocobalamin and fructose Appl Environ Microbiol. 1999 Oct;65(10):4537-42.
9: Gimsing P. Determination of cobalamins in biological material. I. Improvement in the unequal recovery of cobalamins by preincubation with cadmium acetate Anal Biochem. 1983 Mar;129(2):288-95.
10: Astier A, Baud FJ. Simultaneous determination of hydroxocobalamin and its cyanide complex cyanocobalamin in human plasma by high-performance liquid chromatography. Application to pharmacokinetic studies after high-dose hydroxocobalamin as an antidote for severe cyanide poisoning J Chromatogr B Biomed Appl. 1995 May 5;667(1):129-35.

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