Human Urokinase-type Plasminogen Activator (UPA)

Description

Human Urokinase-type Plasminogen Activator (UPA)
Catalog number: B2014314
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 μg
Molecular Weight or Concentration: 45 kDa
Supplied as: Powder
Applications: molecular tool for various biochemical applications
Storage: −20°C
Keywords: ATF, BDPLT5, PLAU, QPD, UPA, URK, Urokinase, u-PA
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Dinesh P, Rasool M. uPA/uPAR signaling in rheumatoid arthritis: Shedding light on its mechanism of action Pharmacol Res. 2018 Aug;134:31-39.
2: Dass K, Ahmad A, Azmi AS, Sarkar SH, Sarkar FH. Evolving role of uPA/uPAR system in human cancers Cancer Treat Rev. 2008 Apr;34(2):122-36.
3: Su SC, Lin CW, Yang WE, Fan WL, Yang SF. The urokinase-type plasminogen activator (uPA) system as a biomarker and therapeutic target in human malignancies Expert Opin Ther Targets. 2016;20(5):551-66.
4: Fang C, Zhong Z, Zhang T, Jia S, Ding X, Zhou W, Wang X. Human hair derived uPA loaded capsules with dual near-infrared (I and II biowindows) laser responsive capabilities for multi-effective thrombolysis therapy J Mater Chem B. 2020 Dec 21;8(47):10854-10866.
5: Dreymann N, Wuensche J, Sabrowski W, Moeller A, Czepluch D, Vu Van D, Fuessel S, Menger MM. Inhibition of Human Urokinase-Type Plasminogen Activator (uPA) Enzyme Activity and Receptor Binding by DNA Aptamers as Potential Therapeutics through Binding to the Different Forms of uPA Int J Mol Sci. 2022 Apr 28;23(9):4890.
6: S El Salamouni N, Buckley BJ, Jiang L, Huang M, Ranson M, Kelso MJ, Yu H. Disruption of Water Networks is the Cause of Human/Mouse Species Selectivity in Urokinase Plasminogen Activator (uPA) Inhibitors Derived from Hexamethylene Amiloride (HMA) J Med Chem. 2022 Feb 10;65(3):1933-1945.
7: Lakka SS, Bhattacharya A, Mohanam S, Boyd D, Rao JS. Regulation of the uPA gene in various grades of human glioma cells Int J Oncol. 2001 Jan;18(1):71-9.
8: Zhou W. Effect of adenovirusmediated uPA gene transduction on the fibrinolytic activity of human umbilical vein endothelial cells Mol Med Rep. 2014 Nov;10(5):2701-5.
9: Ohshita H, Tateno C. Propagation of Human Hepatocytes in uPA/SCID Mice: Producing Chimeric Mice with Humanized Liver Methods Mol Biol. 2017;1506:91-100.
10: Maduni J. The Urokinase Plasminogen Activator System in Human Cancers: An Overview of Its Prognostic and Predictive Role Thromb Haemost. 2018 Dec;118(12):2020-2036.

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