Human Parkin Protein Active

Description

Human Parkin Protein Active
Catalog number: B2014143
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 5 μg
Molecular Weight or Concentration: N/A
Supplied as: Solution
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: Parkinson juvenile disease protein 2, PARK2, PRKN
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Sliter DA, Martinez J, Hao L, Chen X, Sun N, Fischer TD, Burman JL, Li Y, Zhang Z, Narendra DP, Cai H, Borsche M, Klein C, Youle RJ. Parkin and PINK1 mitigate STING-induced inflammation Nature. 2018 Sep;561(7722):258-262.
2: Eiyama A, Okamoto K. PINK1/Parkin-mediated mitophagy in mammalian cells Curr Opin Cell Biol. 2015 Apr;33:95-101.
3: Pickrell AM, Youle RJ. The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson’s disease Neuron. 2015 Jan 21;85(2):257-73.
4: Nguyen TN, Padman BS, Lazarou M. Deciphering the Molecular Signals of PINK1/Parkin Mitophagy Trends Cell Biol. 2016 Oct;26(10):733-744.
5: Lazarou M, Sliter DA, Kane LA, Sarraf SA, Wang C, Burman JL, Sideris DP, Fogel AI, Youle RJ. The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy Nature. 2015 Aug 20;524(7565):309-314.
6: Bingol B, Tea JS, Phu L, Reichelt M, Bakalarski CE, Song Q, Foreman O, Kirkpatrick DS, Sheng M. The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy Nature. 2014 Jun 19;510(7505):370-5.
7: Kane LA, Lazarou M, Fogel AI, Li Y, Yamano K, Sarraf SA, Banerjee S, Youle RJ. PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity J Cell Biol. 2014 Apr 28;205(2):143-53.
8: Iorio R, Celenza G, Petricca S. Mitophagy: Molecular Mechanisms, New Concepts on Parkin Activation and the Emerging Role of AMPK/ULK1 Axis Cells. 2021 Dec 23;11(1):30.
9: Han YC, Tang SQ, Liu YT, Li AM, Zhan M, Yang M, Song N, Zhang W, Wu XQ, Peng CH, Zhang H, Yang S. AMPK agonist alleviate renal tubulointerstitial fibrosis via activating mitophagy in high fat and streptozotocin induced diabetic mice Cell Death Dis. 2021 Oct 9;12(10):925.
10: Gladkova C, Maslen SL, Skehel JM, Komander D. Mechanism of parkin activation by PINK1 Nature. 2018 Jul;559(7714):410-414.

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