Human Matriptase/ST14 Protein

Product Description

Human Matriptase/ST14 Protein
Catalog number: B2012963
Lot number: Batch Dependent
Expiration Date: Batch dependent
Amount: 10 ug
Molecular Weight or Concentration: 26 kDa
Supplied as: Lyophilized Powder
Applications: molecular tool for various biochemical applications
Storage: -20°C
Keywords: Recombinant Human Matriptase/ST14 Catalytic Domain, CF
Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um.

References:
1: Buzza MS, Martin EW, Driesbaugh KH, Désilets A, Leduc R, Antalis TM. Prostasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway J Biol Chem. 2013 Apr 12;288(15):10328-37.
2: Larsen BR, Steffensen SD, Nielsen NV, Friis S, Godiksen S, Bornholdt J, Soendergaard C, Nonboe AW, Andersen MN, Poulsen SS, Szabo R, Bugge TH, Lin CY, Skovbjerg H, Jensen JK, Vogel LK. Hepatocyte growth factor activator inhibitor-2 prevents shedding of matriptase Exp Cell Res. 2013 Apr 1;319(6):918-29.
3: Wilkinson DJ, Wang H, Habgood A, Lamb HK, Thompson P, Hawkins AR, Désilets A, Leduc R, Steinmetzer T, Hammami M, Lee MS, Craik CS, Watson S, Lin H, Milner JM, Rowan AD. Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms Arthritis Rheumatol. 2017 Aug;69(8):1601-1611.
4: Lanchec E, Désilets A, Béliveau F, Flamier A, Mahmoud S, Bernier G, Gris D, Leduc R, Lavoie C. The type II transmembrane serine protease matriptase cleaves the amyloid precursor protein and reduces its processing to β-amyloid peptide J Biol Chem. 2017 Dec 15;292(50):20669-20682.
5: Velasco G, Cal S, Quesada V, Sánchez LM, López-Otín C. Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins J Biol Chem. 2002 Oct 4;277(40):37637-46.
6: Yuan C, Chen L, Meehan EJ, Daly N, Craik DJ, Huang M, Ngo JC. Structure of catalytic domain of Matriptase in complex with Sunflower trypsin inhibitor-1 BMC Struct Biol. 2011 Jun 22;11:30.
7: Nimishakavi S, Besprozvannaya M, Raymond WW, Craik CS, Gruenert DC, Caughey GH. Activity and inhibition of prostasin and matriptase on apical and basolateral surfaces of human airway epithelial cells Am J Physiol Lung Cell Mol Physiol. 2012 Jul;303(2):L97-106.
8: Chai AC, Robinson AL, Chai KX, Chen LM. Ibuprofen regulates the expression and function of membrane-associated serine proteases prostasin and matriptase BMC Cancer. 2015 Dec 29;15:1025.
9: Darragh MR, Schneider EL, Lou J, Phojanakong PJ, Farady CJ, Marks JD, Hann BC, Craik CS. Tumor detection by imaging proteolytic activity Cancer Res. 2010 Feb 15;70(4):1505-12.
10: Wadhawan V, Kolhe YA, Sangith N, Gautam AK, Venkatraman P. From prediction to experimental validation: desmoglein 2 is a functionally relevant substrate of matriptase in epithelial cells and their reciprocal relationship is important for cell adhesion Biochem J. 2012 Oct 1;447(1):61-70.

Products Related to Human Matriptase/ST14 Protein can be found at Proteins