Interleukin-1 beta (IL-1B, Human, Recombinant)


Catalog Number: B2010263 (10 ug)
Human Interleukin-1 beta (IL-1B) is a high quality research product used as highly pure recombinant human Interleukin 1 beta (expressed in CHO cells). IL-1 is thought to regulate the inflammatory response and is involved in cell proliferation, differentiation, and apoptosis. Custom bulk orders of this product are available upon request.

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SKU: B2010263 Categories: ,


Interleukin-1 beta (IL-1B, Human, Recombinant)
Catalog number: B2010263
Lot number: Batch Dependent
Expiration Date: Batch dependent
Volume/Weight: 10 ug
pH: n/a
Supplied as: Reconstitute before use
Appearance: Solid
Applications: highly pure recombinant human Interleukin 1 beta (expressed in CHO cells). IL-1 is thought to regulate the inflammatory response and is involved in cell proliferation, differentiation, and apoptosis.
Storage: -20C
Keywords: rHuIL-1β; Catabolin; IL1F2; IL1B, IL-1
Grade: Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through0.22 um.

1: Libby P. Interleukin-1 Beta as a Target for Atherosclerosis Therapy:
Biological Basis of CANTOS and Beyond. J Am Coll Cardiol. 2017 Oct

2: Simanski M, Erkens AS, Rademacher F, Harder J. Staphylococcus epidermidis-
induced Interleukin-1 Beta and Human Beta-defensin-2 Expression in Human
Keratinocytes is Regulated by the Host Molecule A20 (TNFAIP3). Acta Derm
Venereol. 2019 Feb 1;99(2):181-187.

3: Brown S, Boules M, Hamza N, Wang X, Whalen M. Synthesis of interleukin 1 beta
and interleukin 6 in human lymphocytes is stimulated by tributyltin. Arch
Toxicol. 2018 Aug;92(8):2573-2586.

4: de Koning HD, Schalkwijk J, Stoffels M, Jongekrijg J, Jacobs JF, Verwiel E,
Koenen HJ, Preijers F, Holzinger D, Joosten I, van der Meer JW, Simon A. The
role of interleukin-1 beta in the pathophysiology of Schnitzler’s syndrome.
Arthritis Res Ther. 2015 Jul 22;17(1):187.

5: van den Akker GG, van Beuningen HM, Vitters EL, Koenders MI, van de Loo FA,
van Lent PL, Blaney Davidson EN, van der Kraan PM. Interleukin 1 β-induced
SMAD2/3 linker modifications are TAK1 dependent and delay TGFβ signaling in
primary human mesenchymal stem cells. Cell Signal. 2017 Dec;40:190-199.

6: Ellul P, Boyer L, Groc L, Leboyer M, Fond G. Interleukin-1 β-targeted
treatment strategies in inflammatory depression: toward personalized care. Acta
Psychiatr Scand. 2016 Dec;134(6):469-484.

7: Li P, Yang G, Geng X, Shi J, Li B, Wang Z, Zhang Q, Yang Y, Xu C. High-Level
Secretory Expression and Purification of Recombinant Human Interleukin 1 Beta in
Pichia pastoris. Protein Pept Lett. 2016;23(8):763-9.

8: Fujita T, Ashikaga A, Shiba H, Kajiya M, Kishimoto A, Hirata R, Tsunekuni N,
Hirono C, Kawaguchi H, Shiba Y, Kurihara H. Irsogladine maleate counters the
interleukin-1 beta-induced suppression in gap-junctional intercellular
communication but does not affect the interleukin-1 beta-induced zonula
occludens protein-1 levels in human gingival epithelial cells. J Periodontal
Res. 2008 Feb;43(1):96-102.

9: Xiang J, Li C, Dong W, Cao Z, Liu L. Expression of matrix
metalloproteinase-1, matrix metalloproteinase-2 and extracellular
metalloproteinase inducer in human periodontal ligament cells stimulated with
interleukin-1 beta. J Periodontal Res. 2009 Dec;44(6):784-93.

10: Luo DD, Fielding C, Phillips A, Fraser D. Interleukin-1 beta regulates
proximal tubular cell transforming growth factor beta-1 signalling. Nephrol Dial
Transplant. 2009 Sep;24(9):2655-65.

11: Zheng W, Wang J, Si X, Chen M. Interleukin-1 Beta +3594 C/T Gene
Polymorphism and Susceptibility to Sepsis: A Meta-Analysis. Crit Rev Eukaryot
Gene Expr. 2018;28(4):311-319.

12: Ovaskainen Y, Koponen H, Jokelainen J, Keinänen-Kiukaanniemi S, Kumpusalo E,
Vanhala M. Depressive symptomatology is associated with decreased interleukin-1
beta and increased interleukin-1 receptor antagonist levels in males. Psychiatry
Res. 2009 May 15;167(1-2):73-9.
13: Chang ZK, Meng FG, Zhang ZQ, Mao GP, Huang ZY, Liao WM, He AS.
MicroRNA-193b-3p regulates matrix metalloproteinase 19 expression in
interleukin-1β-induced human chondrocytes. J Cell Biochem. 2018

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